Natural inhibitors targeting osteoclast-mediated bone resorption
文献类型：期刊论文
| 作者 | Zeng, Guang-Zhi; Tan, Ning-Hua; Hao, Xiao-Jiang ; Mu, Quan-Zhang; Li, Rong-Tao
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2006-12-15 |
| 卷号 | 16期号:24页码:6178-6180 |
| 关键词 | Cathepsin k Matrix Metalloproteinase 9 Alpha v Beta(3) Natural Inhibitor Bone Resorption |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2006.09.042 |
| 文献子类 | Article |
| 英文摘要 | Human cathepsin K, matrix metalloproteinase 9, and alpha(V)beta(3) integrin are the key regulators in osteoclast-mediated bone resorption. In this paper, we found natural inhibitors 1-10 for them by enzyme inhibition assays. Inhibitors 1-7, 8-9, and 10 are novel inhibitors of human cathepsin K, matrix metalloproteinase 9, and alpha(V)beta(3), respectively. (c) 2006 Elsevier Ltd. All rights reserved. |
| 学科主题 | Chemistry ; Medicinal ; Chemistry ; Organic |
| WOS关键词 | CATHEPSIN-K ; INTEGRIN ANTAGONISTS ; IIB-IIIA ; FIBRINOGEN ; SUBSTRATE ; BINDING ; PEPTIDE ; MMP-9 |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000242674100006 |
| 公开日期 | 2011-11-24 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/2133]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zeng, Guang-Zhi,Tan, Ning-Hua,Hao, Xiao-Jiang,et al. Natural inhibitors targeting osteoclast-mediated bone resorption[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2006,16(24):6178-6180. |
| APA | Zeng, Guang-Zhi,Tan, Ning-Hua,Hao, Xiao-Jiang,Mu, Quan-Zhang,&Li, Rong-Tao.(2006).Natural inhibitors targeting osteoclast-mediated bone resorption.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,16(24),6178-6180. |
| MLA | Zeng, Guang-Zhi,et al."Natural inhibitors targeting osteoclast-mediated bone resorption".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 16.24(2006):6178-6180. |
入库方式： OAI收割
来源：昆明植物研究所
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