Steroidal saponins and cytoxicity of the wild edible vegetable-Smilacina atropurpurea
文献类型：期刊论文
| 作者 | Yang, Shun-Li1; Liu, Xi-Kui1; Wu, Hui2; Wang, Hai-Bo1; Qing, Chen2 |
| 刊名 | STEROIDS
 |
| 出版日期 | 2009 |
| 卷号 | 74期号:1页码:7-12 |
| 关键词 | Smilacina Atropurpurea Cytoxicity Smilacinoside A-d Steroidal Saponin |
| ISSN号 | 0039-128X |
| DOI | 10.1016/j.steroids.2008.08.008 |
| 文献子类 | Article |
| 英文摘要 | Four new steroidal saponins, smilacinoside A (1), B (2), C (3), and D (4), together with three known saponins, funkioside D (5), aspidistrin (6) and 26-O-beta-D-glucopyranosyl-22-methoxyl-(25R)-furost-5-en-3 beta,26-diol-3-O-beta-D-glucopyranosyl-(1 -> 2)-beta-D-glucopyranosyl-(1 -> 4)-beta-D-galactopyranoside (7) were isolated from the dried tender aerial parts of Smilacina atropurpurea (Franch.) Wang et Tang. The structures of new compounds were elucidated as diosgenin 3-O-alpha-L-rhamnopyranosyl-(1 -> 2)-O-beta-D-galactopyranoside (1), diosgenin 3-O-alpha-L-rhamnopyranosyl-(1 -> 3)-[6-O-palmitoxyl]-O-beta-D-galactopyranoside (2), 26-O-beta-D-glucopyrariosyl-(25R)-furost-5-en-3 beta,22 xi,26-triol 3-O-alpha-L-rhamnopyranosyl-(1 -> 2)}-beta-D-galactopyrarioside (3) and 26-O-beta-D-glucopyranosyl-22-methoxyl-(25R)-furost-5-en-3 beta,26-diol 3-O-alpha-L-rhamnopyranosyl-(1 -> 2)-beta-D-galactopyranoside (4) on the basis of chemical methods and detailed spectroscopic analysis, including 1D and 2D NMR techniques and single-crystal X-ray diffraction, respectively. Six of these compounds and MeOH extract were tested for their in vitro cytotoxicity toward K562 human tumor cells by an improved MTT method. Smilacinoside A, funkioside D and aspidistrin exhibited significant in vitro cytotoxicity against K562 with IC(50) values of 1.09, 2.93 and 0.47 mu g/mL, respectively. (C) 2008 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:000262895500002 |
| 资助机构 | Natural Science Foundation of Yunnan Province of China [2005B0049 M, 2000C0001 P] |
| 公开日期 | 2011-12-19 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/2881]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China 2.Kunming Med Coll, Yunnan Pharmacol Lab Nat Prod, Kunming 650031, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Shun-Li,Liu, Xi-Kui,Wu, Hui,et al. Steroidal saponins and cytoxicity of the wild edible vegetable-Smilacina atropurpurea[J]. STEROIDS,2009,74(1):7-12. |
| APA | Yang, Shun-Li,Liu, Xi-Kui,Wu, Hui,Wang, Hai-Bo,&Qing, Chen.(2009).Steroidal saponins and cytoxicity of the wild edible vegetable-Smilacina atropurpurea.STEROIDS,74(1),7-12. |
| MLA | Yang, Shun-Li,et al."Steroidal saponins and cytoxicity of the wild edible vegetable-Smilacina atropurpurea".STEROIDS 74.1(2009):7-12. |
入库方式： OAI收割
来源：昆明植物研究所
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