Anti-HBV agents. Part 2: Synthesis and in vitro anti-hepatitis B virus activities of alisol A derivatives
文献类型：期刊论文
| 作者 | Zhang, Quan1,2; Jiang, Zhi-Yong1; Luo, Jie1; Liu, Ji-Feng1,2; Ma, Yun-Bao1; Guo, Rui-Hua1,2; Zhang, Xue-Mei1 ; Zhou, Jun1; Chen, Ji-Jun1
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| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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| 出版日期 | 2009-04-15 |
| 卷号 | 19期号:8页码:2148-2153 |
| ISSN号 | 0960-894X |
| 关键词 | Anti-hbv Activity Protostane-type Triterpene Alisol a Derivatives Chemical Modification |
| DOI | 10.1016/j.bmcl.2009.02.122 |
| 文献子类 | Article |
| 英文摘要 | Chemical modi. cations were performed on hydroxyl groups at C-11,23,24,25 positions and C-13(17) double bond of alisol A for structure-activity relationship study. Forty-one derivatives of alisol A were synthesized and assayed for their in vitro anti-hepatitis B virus (HBV) activities and cytotoxicities. Of them, 14 compounds were active against HBV surface antigen (HBsAg) and HBV e antigen (HBeAg) secretion in HepG 2.2.15 cells, and the most promising compound 25 exhibited high activities against secretion of HBsAg (IC(50) = 0.028 mM), HBeAg (IC(50) = 0.027 mM) and remarkable selective indices (SI(HBsAg) > 90, SI(HBeAg) > 93). (C) 2009 Elsevier Ltd. All rights reserved. |
| 学科主题 | Chemistry, Medicinal ; Chemistry, Organic |
| WOS关键词 | ANTIVIRAL ACTIVITY ; INHIBITORS ; REPLICATION ; REAGENTS |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000264706800012 |
| 资助机构 | National Natural Science Foundation of China (NSFC) [30672522]; Xibu Zhiguang Joint-Scholarship of Chinese Academy of Sciences ; External Cooperation Program of Chinese Academy of Sciences [GJHZ200818]; CAS-Croucher Foundation [CAS-CF07/08.SC03] |
| 公开日期 | 2011-12-19 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/2913]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Quan,Jiang, Zhi-Yong,Luo, Jie,et al. Anti-HBV agents. Part 2: Synthesis and in vitro anti-hepatitis B virus activities of alisol A derivatives[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2009,19(8):2148-2153. |
| APA | Zhang, Quan.,Jiang, Zhi-Yong.,Luo, Jie.,Liu, Ji-Feng.,Ma, Yun-Bao.,...&Chen, Ji-Jun.(2009).Anti-HBV agents. Part 2: Synthesis and in vitro anti-hepatitis B virus activities of alisol A derivatives.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,19(8),2148-2153. |
| MLA | Zhang, Quan,et al."Anti-HBV agents. Part 2: Synthesis and in vitro anti-hepatitis B virus activities of alisol A derivatives".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 19.8(2009):2148-2153. |
入库方式： OAI收割
来源：昆明植物研究所
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