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Cytotoxic alkaloids from the bulbs of Fritillaria hupehensis

文献类型：期刊论文

作者Zhang, Yong-Hui1; Yang, Xi-Liang1; Zhang, Peng1; Zhou, Xue-Feng1; Ruan, Han-Li1; Pi, Hui-Fang1; Wu, Ji-Zhou1; Sun, Han-Dong2
刊名CHEMISTRY & BIODIVERSITY
出版日期2008
卷号5期号:2页码:259-266
ISSN号1612-1872
通讯作者ywjz@mails.tjmu.edu.cn
文献子类Article
英文摘要Phytochemical investigation of the bulbs of Fritillaria hupehensis resulted in the isolation and structural elucidation of four new steroidal penta- and hexacyclic veratraman- and cevan-based alkaloids, respectively, compounds 1-4. They were obtained together with the known constituents ebeinine (5) and zhebeinine (6), which were isolated for the first time from this plant. The structures of the new isolates were established by spectroscopic and mass-spectrometric analyses, in combination with chemical methods. All compounds were assayed for their cytotoxic effects towards HeLa and HepG2 cell lines. Compounds 1 and 2 showed significant inhibitory effects against both types of tumor cells, with IC50 values in the range 2.52-0.23 mu M, similar as those for 5-fluorouracil used as positive control.
学科主题Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000253749100004
公开日期2011-12-19
源URL[http://ir.kib.ac.cn:8080/handle/151853/2945]  
专题昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Huazhong Univ Sci & Technol, Tongji Med Coll, Fac Pharmaceut Sci, Wuhan 430030, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Yong-Hui,Yang, Xi-Liang,Zhang, Peng,et al. Cytotoxic alkaloids from the bulbs of Fritillaria hupehensis[J]. CHEMISTRY & BIODIVERSITY,2008,5(2):259-266.
APA Zhang, Yong-Hui.,Yang, Xi-Liang.,Zhang, Peng.,Zhou, Xue-Feng.,Ruan, Han-Li.,...&Sun, Han-Dong.(2008).Cytotoxic alkaloids from the bulbs of Fritillaria hupehensis.CHEMISTRY & BIODIVERSITY,5(2),259-266.
MLA Zhang, Yong-Hui,et al."Cytotoxic alkaloids from the bulbs of Fritillaria hupehensis".CHEMISTRY & BIODIVERSITY 5.2(2008):259-266.

入库方式： OAI收割

来源：昆明植物研究所

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