Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, induces cell-cycle arrest in G1 phase via the ERK1/2 pathway
文献类型：期刊论文
| 作者 | Ye, Mao1,3; Luo, Xiangjian1; Li, Lili1; Shi, Ying1; Tan, Ming1; Weng, Xinxian1; Li, Wei1; Liu, Jikai2; Cao, Ya1 |
| 刊名 | CANCER LETTERS
 |
| 出版日期 | 2007-12-18 |
| 卷号 | 258期号:2页码:199-207 |
| 关键词 | Grifolin Cell Cycle Erk1/2 Erk5 |
| ISSN号 | 0304-3835 |
| DOI | 10.1016/j.canlet.2007.09.001 |
| 通讯作者 | ycao98@vip.sina.com |
| 文献子类 | Article |
| 英文摘要 | Grifolin, a natural product isolated from the mushroom Albatrellus confluens, has been shown to inhibit the growth of some cancer cell lines and induce significant apoptosis. However, the molecular targets and the signaling mechanism underlying the anticancer effect of this compound are not completely understood. Here, we undertook a gene expression profiling study to identify novel targets of grifolin. We found that the effect of grifolin on the human nasopharyngeal carcinoma cell line CNE1 occurs primarily via the ERK1/2 pathway. At high doses, both the ERK1/2 and the ERK5 pathways may be involved in the inhibition. Because inhibition of the ERK1/2 or the ERK5 pathway has been associated with cell-cycle arrest and growth inhibition, we evaluated the cell cycle distribution after grifolin treatment. We found that grifolin significantly caused cell-cycle arrest in G1 phase. To investigate the underlying mechanisms, G1-related proteins were assayed by Western blotting. Following grifolin treatment, a concomitant inhibition of cyclin D1, cyclin E, CDK4 expression, and subsequent reduction in pRB phosphorylation occurred. Meanwhile, grifolin treatment also resulted in a significant upregulation of CKI (p19(INK4D)). These results suggest that the inhibition of the ERK1/2 or the ERK5 pathway is responsible for at least part of the induction of cell-cycle arrest in G1 phase by grifolin. These results are significant in that they provide a mechanistic framework for further exploring the use of grifolin as a novel antitumor agent. (c) 2007 Elsevier Ireland Ltd. All rights reserved. |
| 学科主题 | Oncology |
| WOS关键词 | SIGNAL-REGULATED KINASE ; NASOPHARYNGEAL CARCINOMA ; APOPTOSIS ; PROLIFERATION ; OVEREXPRESSION ; TRANSDUCTION ; DERIVATIVES ; INHIBITION ; ACTIVATION ; EXPRESSION |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000251852600006 |
| 公开日期 | 2011-12-19 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/2951]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.S Cent Univ, Xiangya Sch Med, Canc Res Inst, Changsha 410078, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Dept Phytochem, Kunming 650204, Peoples R China 3.Wenzhou Med Coll, Sch Ophthalmol & Optometry, Zhejiang 325027, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ye, Mao,Luo, Xiangjian,Li, Lili,et al. Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, induces cell-cycle arrest in G1 phase via the ERK1/2 pathway[J]. CANCER LETTERS,2007,258(2):199-207. |
| APA | Ye, Mao.,Luo, Xiangjian.,Li, Lili.,Shi, Ying.,Tan, Ming.,...&Cao, Ya.(2007).Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, induces cell-cycle arrest in G1 phase via the ERK1/2 pathway.CANCER LETTERS,258(2),199-207. |
| MLA | Ye, Mao,et al."Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, induces cell-cycle arrest in G1 phase via the ERK1/2 pathway".CANCER LETTERS 258.2(2007):199-207. |
入库方式： OAI收割
来源：昆明植物研究所
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