Highly Functionalized Daphnane Diterpenoids from Trigonostemon thyrsoideum
文献类型：期刊论文
| 作者 | Zhang, Ling1,4; Luo, Rong-Hua2,3; Wang, Fei1; Jiang, Meng-Yuan1,4; Dong, Ze-Jun1 ; Yang, Liu-Meng2,3; Zheng, Yong-Tang2,3; Liu, Ji-Kai1
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2010 |
| 卷号 | 12期号:1页码:152-155 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/ol9025638 |
| 文献子类 | Article |
| 英文摘要 | Trigonothyrins A-C (1-3), which are highly functionalized daphnane diterpenoids, were isolated from the stems of Trigonostemon thyrsoideum. Compounds 1-3 represent the first examples of daphnanes with an oxygen-bridged four-membered-ring system, and a linkage mode of 12,13,14-orthoester. Compound 3 was observed to inhibit HIV-1 induced cytopathic effects. The EC(50) value was 2.19 mu g/mL, and the therapeutic index (TI) was more than 90. |
| 学科主题 | Chemistry, Organic |
| WOS关键词 | REIDIOIDES ; PLANT ; REDIOCIDE ; GENKWA ; ROOTS ; CELLS |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000272937200039 |
| 资助机构 | National Basic Research Program of China [2009CB522300]; National Natural Science Foundation of China [30830113] |
| 公开日期 | 2012-03-21 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/4012]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China 3.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Peoples R China 4.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Ling,Luo, Rong-Hua,Wang, Fei,et al. Highly Functionalized Daphnane Diterpenoids from Trigonostemon thyrsoideum[J]. ORGANIC LETTERS,2010,12(1):152-155. |
| APA | Zhang, Ling.,Luo, Rong-Hua.,Wang, Fei.,Jiang, Meng-Yuan.,Dong, Ze-Jun.,...&Liu, Ji-Kai.(2010).Highly Functionalized Daphnane Diterpenoids from Trigonostemon thyrsoideum.ORGANIC LETTERS,12(1),152-155. |
| MLA | Zhang, Ling,et al."Highly Functionalized Daphnane Diterpenoids from Trigonostemon thyrsoideum".ORGANIC LETTERS 12.1(2010):152-155. |
入库方式： OAI收割
来源：昆明植物研究所
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