Anti-human Immunodeficiency Virus-1 Constituents of the Bark of Poncirus trifoliata
文献类型：期刊论文
| 作者 | Feng, Tao3,4; Wang, Rui-Rui1,2; Cai, Xiang-Hai4 ; Zheng, Yong-Tang1,2; Luo, Xiao-Dong4
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| 刊名 | CHEMICAL & PHARMACEUTICAL BULLETIN
 |
| 出版日期 | 2010-07-01 |
| 卷号 | 58期号:7页码:971-975 |
| 关键词 | Poncirus Trifoliata Chemical Constituent Prenylated Flavonoid Anti-human Immunodeficiency Virus-1 Activity |
| ISSN号 | 0009-2363 |
| 文献子类 | Article |
| 英文摘要 | A total of 36 compounds (1-36) were obtained from the stem bark of Poncirus trifoliata including three new prenylated flavonoids, (-)-5,4'-dihydroxy-7,8-[(3 '',4 ''-cis-dihydroxy-3 '',4 ''-dihydro)-2 '',2 ''-dimethylpyrano]-flavone (1), (-)-5,4'-dihydroxy-7,8-[(3 ''-hydroxy-4 ''-one)-2 '',2 ''-dimethylpyrano]-flavone (2), and (-)-5,4'-dihydroxy-7,8-[(cis-3 ''-hydroxy-4 ''-ethoxy-3 '',4 ''-dihydro)-2 '',2 ''-dimethylpyrano]-flavone (3). The new structures were elucidated by means of spectroscopic methods. Compounds 1-20 were evaluated for their anti-human immunodeficiency virus-1 (HIV-1) activity, in which 2 showed significant anti-HIV-1 activity with high therapeutic index (T1) of 143.65. |
| 学科主题 | Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| WOS关键词 | CITRUS BITTER PRINCIPLES ; CHEMICAL-CONSTITUENTS ; BINARY COUMARINS ; ROOT BARK ; PLANTS ; FLAVONOIDS ; FRUITS ; CELLS |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000279213500019 |
| 资助机构 | Ministry of Science and Technology of P.R. China [2009CB522300]; Chinese Academy of Sciences |
| 公开日期 | 2012-03-21 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/4112]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China 2.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 4.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, Tao,Wang, Rui-Rui,Cai, Xiang-Hai,et al. Anti-human Immunodeficiency Virus-1 Constituents of the Bark of Poncirus trifoliata[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2010,58(7):971-975. |
| APA | Feng, Tao,Wang, Rui-Rui,Cai, Xiang-Hai,Zheng, Yong-Tang,&Luo, Xiao-Dong.(2010).Anti-human Immunodeficiency Virus-1 Constituents of the Bark of Poncirus trifoliata.CHEMICAL & PHARMACEUTICAL BULLETIN,58(7),971-975. |
| MLA | Feng, Tao,et al."Anti-human Immunodeficiency Virus-1 Constituents of the Bark of Poncirus trifoliata".CHEMICAL & PHARMACEUTICAL BULLETIN 58.7(2010):971-975. |
入库方式： OAI收割
来源：昆明植物研究所
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