Effects of spiramine T on antioxidant enzymatic activities and nitric oxide production in cerebral ischemia-reperfusion gerbils
文献类型：期刊论文
| 作者 | Li, L ; Shen, YM; Yang, XS; Wu, WL; Wang, BG; Chen, ZH; Hao, XJ
|
| 刊名 | BRAIN RESEARCH
 |
| 出版日期 | 2002-07-19 |
| 卷号 | 944期号:1-2页码:205-209 |
| 关键词 | Spiraea Japonica Var. Acuta Rosaceae Spiramine t Cerebral Ischemia-reperfusion Antioxidant Enzyme Nitric Oxide Synthase |
| ISSN号 | 0006-8993 |
| 文献子类 | Article |
| 英文摘要 | Spiramine T, an atisine-type diterpene alkaloid isolated from the Chinese herbal medicine Spiraea japonica var. acuta (Rosaceae), was shown to have neuroprotective effects on cerebral ischemia-reperfusion injury. In this study, the effects of spiramine T on antioxidant enzymes and nitric oxide production were evaluated in gerbils subjected to global forebrain ischemia (10 min) and reperfusion (5 days). Spiramine T (1.0 and 2.0 mg kg(-1) i.p.) markedly reduced the content of lipid peroxide (LPO), increased the glutathione peroxidase (GSH-PX) activity, and inhibited the increase of nitric oxidase (NOS) activity and nitric oxide production in the cortex during ischemia-reperfusion in gerbils. These results suggested that the neuroprotective effects of spiramine T were related to modulation of endogenous antioxidant enzymatic activities and reduction of the formation of nitric oxide. (C) 2002 Elsevier Science B.V. All rights reserved. |
| 学科主题 | Neurosciences |
| WOS关键词 | SPIRAEA-JAPONICA ; GLUTATHIONE-PEROXIDASE ; SUPEROXIDE-DISMUTASE ; ARTERY OCCLUSION ; TRANSGENIC MICE ; BRAIN INJURY ; SYNTHASE ; ALKALOIDS ; INDUCTION ; PROTECTS |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000177224100023 |
| 公开日期 | 2012-03-21 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/4132]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Yunnan, Peoples R China 2.Kunming Med Coll, Yunnan Pharmacol Labs Nat Prod, Kunming 650031, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, L,Shen, YM,Yang, XS,et al. Effects of spiramine T on antioxidant enzymatic activities and nitric oxide production in cerebral ischemia-reperfusion gerbils[J]. BRAIN RESEARCH,2002,944(1-2):205-209. |
| APA | Li, L.,Shen, YM.,Yang, XS.,Wu, WL.,Wang, BG.,...&Hao, XJ.(2002).Effects of spiramine T on antioxidant enzymatic activities and nitric oxide production in cerebral ischemia-reperfusion gerbils.BRAIN RESEARCH,944(1-2),205-209. |
| MLA | Li, L,et al."Effects of spiramine T on antioxidant enzymatic activities and nitric oxide production in cerebral ischemia-reperfusion gerbils".BRAIN RESEARCH 944.1-2(2002):205-209. |
入库方式： OAI收割
来源：昆明植物研究所
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