Efficient synthesis of galactosylceramide analogues for iNKT cell stimulation
文献类型：期刊论文
| 作者 | Wenlan Chen; Chengfeng Xia; Li Cai; Peng George Wanga |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2010-07-01 |
| 卷号 | 20期号:13页码:3859-3862 |
| 关键词 | Nkt Cells Glycolipid Ceramide |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2010.05.045 |
| 文献子类 | Article |
| 英文摘要 | Glycolipids are potential antigens for iNKT cells recognition and demonstrate important roles in both innate and adaptive immunity. However, the difficulties in the preparation of pure configuration defined glycolipids limit the exploration of their different profiles in activating iNKT cells. We report here a concise and stereospecific preparation of novel galactosylceramide analogues by oxime ligation. This strategy would provide an efficient way to generate varied glycolipid analogues with either synthetic or natural carbohydrates for biological evaluations. (c) 2010 Elsevier Ltd. All rights reserved. |
| 学科主题 | Chemistry, Medicinal ; Chemistry, Organic |
| WOS关键词 | KILLER T-CELLS ; ALPHA-GALACTOSYLCERAMIDE ; NKT CELLS ; ISOGLOBOTRIHEXOSYLCERAMIDE ; AGONIST ; ACTIVATION ; RESPONSES ; CERAMIDE ; KRN7000 ; LIGAND |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000278644700005 |
| 资助机构 | Ohio State University ; NIH [R21AI083513] |
| 公开日期 | 2012-03-21 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/4142]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Wenlan Chen,Chengfeng Xia,Li Cai,et al. Efficient synthesis of galactosylceramide analogues for iNKT cell stimulation[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2010,20(13):3859-3862. |
| APA | Wenlan Chen,Chengfeng Xia,Li Cai,&Peng George Wanga.(2010).Efficient synthesis of galactosylceramide analogues for iNKT cell stimulation.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,20(13),3859-3862. |
| MLA | Wenlan Chen,et al."Efficient synthesis of galactosylceramide analogues for iNKT cell stimulation".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20.13(2010):3859-3862. |
入库方式： OAI收割
来源：昆明植物研究所
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