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Antiproliferative activity of the main constituents from Phyllanthus emblica

文献类型：期刊论文

作者Zhang, YJ; Nagao, T; Tanaka, T; Yang, CR; Okabe, H; Kouno, I
刊名BIOLOGICAL & PHARMACEUTICAL BULLETIN
出版日期2004-02-01
卷号27期号:2页码:251-255
关键词Phyllanthus Emblica Euphorbiaceae Antiproliferative Activity Mk-1 Cell Hela Cell B16f10 Cell
ISSN号0918-6158
文献子类Article
英文摘要Eighteen main compounds, including four norsesquiterpenoids (1-4) and 14 phenolic compounds (5-18) isolated previously from Phyllanthus emblica, together with a main constituent, proanthocyanidin polymers (19) identified at this time from the roots, were estimated for their antiproliferative activities against MK-1 (human gastric adenocarcinoma), HeLa (human uterine carcinoma), and B16F10 (murine melanoma) cells using an MTT method. All of the phenolic compounds including the major components 5-8 from the fruit juice, 8, 9, and 12 from the branches and leaves, and 19 from the roots showed stronger inhibition against B16F10 cell growth than against HeLa and MK-1 cell growth. Norsesquiterpenoid glycosides 3 and 4 from the roots exhibited significant antiproliferative activities, although their aglycon 1 and monoglucoside 2 showed no inhibitory activity against these tumor cells.
学科主题Pharmacology & Pharmacy
WOS关键词EXTRACT ; LEAVES ; PLANTS ; SEEDS ; FRUIT ; ROOTS
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000188653900025
公开日期2012-03-21
源URL[http://ir.kib.ac.cn:8080/handle/151853/4160]  
专题昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Nagasaki Univ, Fac Pharmaceut Sci, Nagasaki 8528521, Japan
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
3.Fukuoka Univ, Fac Pharmaceut Sci, Jonan Ku, Fukuoka 8140180, Japan
推荐引用方式
GB/T 7714		 Zhang, YJ,Nagao, T,Tanaka, T,et al. Antiproliferative activity of the main constituents from Phyllanthus emblica[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2004,27(2):251-255.
APA Zhang, YJ,Nagao, T,Tanaka, T,Yang, CR,Okabe, H,&Kouno, I.(2004).Antiproliferative activity of the main constituents from Phyllanthus emblica.BIOLOGICAL & PHARMACEUTICAL BULLETIN,27(2),251-255.
MLA Zhang, YJ,et al."Antiproliferative activity of the main constituents from Phyllanthus emblica".BIOLOGICAL & PHARMACEUTICAL BULLETIN 27.2(2004):251-255.

入库方式： OAI收割

来源：昆明植物研究所

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