Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus
文献类型：期刊论文
| 作者 | Wang, Q ; Ding, ZH; Liu, JK; Zheng, YT
|
| 刊名 | ANTIVIRAL RESEARCH
 |
| 出版日期 | 2004-12-01 |
| 卷号 | 64期号:3页码:189-194 |
| 关键词 | Xanthohumol Anti-hiv-1 Flavonoid Reverse Transcriptase Hiv Entry |
| ISSN号 | 0166-3542 |
| DOI | 10.1016/j.antiviral.2004.08.005 |
| 文献子类 | Article |
| 英文摘要 | Xanthohumol, prenylchacone flavonoid, is a natural product with multi-biofunctions purified from Hops Humulus lupulus. Its anti-HIV-1 activity was tested in the present study. Results showed that xanthohumol inhibited HIV-1 induced cytopathic effects, the production of viral p24 antigen and reverse transcriptase in C8166 lymphocytes at non-cytotoxic concentration. The EC50 values were 0.82, 1.28 and 0.50 mug/ml, respectively. The therapeutic index (TI) was about 10.8. Xanthohumol also inhibited HIV-1 replication in PBMC with EC50 value of 20.74 mug/ml. The activity of recombinant HIV-1 reverse transcriptase and the HIV-1 entry were not inhibited by xanthohumol. The results from this study suggested that xanthohumol is effective against HIV-1 and might serve as an interesting lead compound. It may represent a novel chemotherapeutic agent for HIV-1 infection. However, the mechanism of its anti-HIV-1 effect needs to be further clarified. (C) 2004 Elsevier B.V. All rights reserved. |
| 学科主题 | Pharmacology & Pharmacy ; Virology |
| WOS关键词 | REVERSE-TRANSCRIPTASE INHIBITORS ; IN-VITRO ; PRENYLATED FLAVONOIDS ; CELLS ; TRICHOSANTHIN ; ACTIVATION ; CHALCONES ; INFECTION ; ENTRY |
| WOS研究方向 | Pharmacology & Pharmacy ; Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000225626000005 |
| 公开日期 | 2012-03-21 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/4178]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources, Kunming 650204, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Q,Ding, ZH,Liu, JK,et al. Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus[J]. ANTIVIRAL RESEARCH,2004,64(3):189-194. |
| APA | Wang, Q,Ding, ZH,Liu, JK,&Zheng, YT.(2004).Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus.ANTIVIRAL RESEARCH,64(3),189-194. |
| MLA | Wang, Q,et al."Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus".ANTIVIRAL RESEARCH 64.3(2004):189-194. |
入库方式： OAI收割
来源：昆明植物研究所
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