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Cytotoxic Triterpene Dilactones from the Stems of Kadsura ananosma

文献类型：期刊论文

作者Yang, Jian-Hong1,3; Pu, Jian-Xin1; Wen, Jin2; Li, Xiao-Nian1; He, Fei1; Xue, Yong-Bo1; Wang, Yuan-Yuan1; Li, Yan1; Xiao, Wei-Lie1; Sun, Han-Dong1
刊名JOURNAL OF NATURAL PRODUCTS
出版日期2010
卷号73期号:1页码:12-16
关键词Dibenzocyclooctadiene Lignans Unique Skeleton Coccinea Philippinensis Interior Longipedunculata Heteroclita Acids
ISSN号0163-3864
DOI10.1021/np900506g
文献子类Article
英文摘要Six new triterpene dilactones with a rare rearranged pentacyclic skeleton, longipedlactones K-P (1-6), and seven known analogues (7-13) were isolated from the stems of Kadsura ananosma. Compound I was found to possess a unique peroxide bridge between C-1 and C-9 in rings A and B. The structures of these new compounds were established on the basis of spectroscopic data analysis, especially of their 2D NMR spectra. In the evaluation of the in vitro cytotoxicity of these compounds against a small panel of human cancer cell lines, compounds 3, 7, 9, and 13 were found to be the most potent against HL-60 acute leukemia cell.
学科主题Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS关键词DIBENZOCYCLOOCTADIENE LIGNANS ; UNIQUE SKELETON ; COCCINEA ; PHILIPPINENSIS ; INTERIOR ; LONGIPEDUNCULATA ; HETEROCLITA ; ACIDS
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000273654000004
资助机构NSFC [30830115, 2008GA031]; Major State Basic Research Development Program of China [2009CB522300, 2009CB940900]; Western Doctoral Foundation of Chinese Academy of Sciences ; Drug Development front Five Medicinal Plants in West China [KZCX2-XB2-15]
公开日期2012-03-21
源URL[http://ir.kib.ac.cn:8080/handle/151853/4232]  
专题昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Yunnan Acad Forest Sci, Inst Trop Forestry, Beijing 100039, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Jian-Hong,Pu, Jian-Xin,Wen, Jin,et al. Cytotoxic Triterpene Dilactones from the Stems of Kadsura ananosma[J]. JOURNAL OF NATURAL PRODUCTS,2010,73(1):12-16.
APA Yang, Jian-Hong.,Pu, Jian-Xin.,Wen, Jin.,Li, Xiao-Nian.,He, Fei.,...&Sun, Han-Dong.(2010).Cytotoxic Triterpene Dilactones from the Stems of Kadsura ananosma.JOURNAL OF NATURAL PRODUCTS,73(1),12-16.
MLA Yang, Jian-Hong,et al."Cytotoxic Triterpene Dilactones from the Stems of Kadsura ananosma".JOURNAL OF NATURAL PRODUCTS 73.1(2010):12-16.

入库方式： OAI收割

来源：昆明植物研究所

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