Swerilactones A and B, Anti-HBV New Lactones from a Tradtional Chinese Herb: Swertia mileensis as a Treatment for Viral Hepatitis
文献类型：期刊论文
| 作者 | Geng, Chang-An1,2 ; Jiang, Zhi-Yong1; Ma, Yun-Bao1; Luo, Jie1; Zhang, Xue-Mei1; Wang, Hong-Ling1,2; Shen, Yong1,2; Zuo, Ai-Xue1,2; Zhou, Jun1; Chen, Ji-Jun1
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2009-09-17 |
| 卷号 | 11期号:18页码:4120-4123 |
| 关键词 | Lamivudine Therapy Virus Alkaloids Constituents |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/ol901592f |
| 文献子类 | Article |
| 英文摘要 | Swerilactones A (1) and B (2), two novel lactones with an unprecedented 6/6/6/6/6 pentacyclic ring system, were isolated from the traditional Chinese herb of Swertia mileensis with activity against the hepatitis virus. Their structures and relative stereochemistry were elucidated based on spectroscopic methods and further confirmed by X-ray single crystal diffraction analysis. In vitro antihepatitis B virus (HBV) assay on Hep G 2.2.15 cell line showed that compound 1 inhibited HBsAg and HBeAg secretion with IC(50) values of 3.66 and 3.58 mM, respectively. |
| 学科主题 | Chemistry, Organic |
| WOS关键词 | LAMIVUDINE THERAPY ; VIRUS ; ALKALOIDS ; CONSTITUENTS |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000269670700024 |
| 资助机构 | National Natural Science Foundation of China and Yunnan Province [U0832603]; Xibu Zhiguang Joint-Scholarship |
| 公开日期 | 2012-03-21 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/4264]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Geng, Chang-An,Jiang, Zhi-Yong,Ma, Yun-Bao,et al. Swerilactones A and B, Anti-HBV New Lactones from a Tradtional Chinese Herb: Swertia mileensis as a Treatment for Viral Hepatitis[J]. ORGANIC LETTERS,2009,11(18):4120-4123. |
| APA | Geng, Chang-An.,Jiang, Zhi-Yong.,Ma, Yun-Bao.,Luo, Jie.,Zhang, Xue-Mei.,...&Chen, Ji-Jun.(2009).Swerilactones A and B, Anti-HBV New Lactones from a Tradtional Chinese Herb: Swertia mileensis as a Treatment for Viral Hepatitis.ORGANIC LETTERS,11(18),4120-4123. |
| MLA | Geng, Chang-An,et al."Swerilactones A and B, Anti-HBV New Lactones from a Tradtional Chinese Herb: Swertia mileensis as a Treatment for Viral Hepatitis".ORGANIC LETTERS 11.18(2009):4120-4123. |
入库方式： OAI收割
来源：昆明植物研究所
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