中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 昆明植物研究所
  3. 中国科学院昆明植物研究所
  4. 植物化学与西部植物资源持续利用国家重点实验室
Total Synthesis of (-)-8-Deoxyserratinine via an Efficient Helquist Annulation and Double N-Alkylation Reaction

文献类型：期刊论文

作者Yang, Yu-Rong1; Lai, Zeng-Wei1,2; Shen, Liang1; Huang, Jiu-Zhong1,2; Wu, Xing-De1; Yin, Jun-Lin1; Wei, Kun1
刊名ORGANIC LETTERS
出版日期2010-08-06
卷号12期号:15页码:3430-3433
关键词Lycopodium Alkaloids Absolute-configuration Lipogrammistin-a Serratinine 2-nitrobenzenesulfonamide Macrocyclization Serratum
ISSN号1523-7060
DOI10.1021/ol1012444
文献子类Article
英文摘要The first enantioselective total synthesis of (-)-8-deoxyserratinine has been achieved in 15 steps from enone 4 with 7% overall yield. The key features include a highly efficient Helquist annulation to furnish the cis-fused 6/5 bicycle, facile construction of the aza nine-membered ring system employing double N-alkylation strategy, as well as asymmetric Shi epoxidation, delivering the desired beta-epoxide stereospecifically.
学科主题Chemistry, Organic
WOS关键词LYCOPODIUM ALKALOIDS ; ABSOLUTE-CONFIGURATION ; LIPOGRAMMISTIN-A ; SERRATININE ; 2-NITROBENZENESULFONAMIDE ; MACROCYCLIZATION ; SERRATUM
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000280398900038
资助机构National Natural Science of China [20802084]; National Basic Research Program of China (973 Program) [2009 CB522300]; Chinese Academy of Sciences ; State Key Laboratory of Phytochemistry and Plant Resources in West China
公开日期2012-03-21
源URL[http://ir.kib.ac.cn:8080/handle/151853/4288]  
专题昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Yunnan Univ, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Yu-Rong,Lai, Zeng-Wei,Shen, Liang,et al. Total Synthesis of (-)-8-Deoxyserratinine via an Efficient Helquist Annulation and Double N-Alkylation Reaction[J]. ORGANIC LETTERS,2010,12(15):3430-3433.
APA Yang, Yu-Rong.,Lai, Zeng-Wei.,Shen, Liang.,Huang, Jiu-Zhong.,Wu, Xing-De.,...&Wei, Kun.(2010).Total Synthesis of (-)-8-Deoxyserratinine via an Efficient Helquist Annulation and Double N-Alkylation Reaction.ORGANIC LETTERS,12(15),3430-3433.
MLA Yang, Yu-Rong,et al."Total Synthesis of (-)-8-Deoxyserratinine via an Efficient Helquist Annulation and Double N-Alkylation Reaction".ORGANIC LETTERS 12.15(2010):3430-3433.

入库方式： OAI收割

来源：昆明植物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。