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Kansuinone, a novel euphane-type triterpene from Euphorbia kansui

文献类型：期刊论文

作者Guo, Jie1,2; He, Hong-Ping2; Fang, Xin2; Di, Ying-Tong2; Li, Shun-Lin2; Zhang, Zhen2; Leng, Ying3; Hua, Hui-Ming1; Hao, Xiao-Jiang2
刊名TETRAHEDRON LETTERS
出版日期2010-12-01
卷号51期号:48页码:6286-6289
关键词Euphorbia Kansui Euphane-type Triterpene Structure Elucidation 11 Beta-hsd1 Inhibitory Activity
ISSN号0040-4039
DOI10.1016/j.tetlet.2010.09.099
文献子类Article
英文摘要Kansuinone (1), a rearranged euphane triterpenoid containing a spiro [5,61 ring system, was isolated from the roots of Euphorbia kansui. Its structure and stereochemistry were elucidated on the basis of spectro-scopic, CD, and computational methods. Kansuinone (1) exhibited inhibitory activity against human and mouse 11 beta-HSD1 (11 beta-hydroxysteroid dehydrogenase type 1), with IC(50) values of 1.12 and 1.08 mu M, respectively. (C) 2010 Elsevier Ltd. All rights reserved.
学科主题Chemistry, Organic
WOS关键词11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 ; METABOLIC SYNDROME ; OBESITY ; DITERPENOIDS ; ROOTS ; CELLS ; MICE ; BARK
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000284303200021
资助机构Ministry of Science and Technology of China [2009CB940900, 2009CB522300]; National Natural Science Funding of China [21072199]; Natural Science Funding of Yunnan Province [2009CD112]; Foundation of Chinese Academy of Sciences ; Yong Academic and Technical Leader Raising Foundation of Yunnan Province ; Foundation of State Key Laboratory of Phytochemistry and Plant Resource in West China [P2010-ZZ01]
公开日期2012-03-21
源URL[http://ir.kib.ac.cn:8080/handle/151853/4306]  
专题昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Shenyang Pharmaceut Univ, Dept Nat Prod Chem, Shenyang 110016, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Guo, Jie,He, Hong-Ping,Fang, Xin,et al. Kansuinone, a novel euphane-type triterpene from Euphorbia kansui[J]. TETRAHEDRON LETTERS,2010,51(48):6286-6289.
APA Guo, Jie.,He, Hong-Ping.,Fang, Xin.,Di, Ying-Tong.,Li, Shun-Lin.,...&Hao, Xiao-Jiang.(2010).Kansuinone, a novel euphane-type triterpene from Euphorbia kansui.TETRAHEDRON LETTERS,51(48),6286-6289.
MLA Guo, Jie,et al."Kansuinone, a novel euphane-type triterpene from Euphorbia kansui".TETRAHEDRON LETTERS 51.48(2010):6286-6289.

入库方式： OAI收割

来源：昆明植物研究所

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