Crystal and molecular structures of a natural equimolecular mixture of two epimeric diterpenes
文献类型：期刊论文
| 作者 | Sun, HD ; Qiu, SX; Lobkovsky, EB; Lin, LZ; Farnsworth, NR; Clardy, J; Fong, HHS
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| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2001 |
| 卷号 | 57期号:1页码:65-70 |
| 关键词 | Acetals Terpenoids Isodon Irrorata Complexes Epimerisation |
| ISSN号 | 0040-4020 |
| 通讯作者 | Qiu, SX, Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60612 USA |
| 文献子类 | Article |
| 英文摘要 | Irroratin A (1), isolated from the aerial Darts of Isodon irrorata (Forrest.) (Labiatae), was shown to be an equimolecular mixture of two C-20 epimers of a new ent-kaurene diterpene both in the crystalline state and pyridine solution, based on X-ray, LC/MS/MS, FABMS as well as extensive 1D- and 2D-NMR spectral analysis. The two epimers were hound together by hydrogen bonds, and when in chloroform and methanol solution, the 20S-epimer predominates. Irroratin A exhibited potent cytotoxicity against several human cancer cell lines. (C) 2000 Elsevier Science Ltd. All rights reserved. |
| 学科主题 | Chemistry, Organic |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000166224300006 |
| 公开日期 | 2012-03-21 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/4524]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60612 USA 2.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China 3.Cornell Univ, Dept Chem, Baker Lab, Ithaca, NY 14850 USA |
| 推荐引用方式 GB/T 7714 | Sun, HD,Qiu, SX,Lobkovsky, EB,et al. Crystal and molecular structures of a natural equimolecular mixture of two epimeric diterpenes[J]. TETRAHEDRON,2001,57(1):65-70. |
| APA | Sun, HD.,Qiu, SX.,Lobkovsky, EB.,Lin, LZ.,Farnsworth, NR.,...&Fong, HHS.(2001).Crystal and molecular structures of a natural equimolecular mixture of two epimeric diterpenes.TETRAHEDRON,57(1),65-70. |
| MLA | Sun, HD,et al."Crystal and molecular structures of a natural equimolecular mixture of two epimeric diterpenes".TETRAHEDRON 57.1(2001):65-70. |
入库方式： OAI收割
来源：昆明植物研究所
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