New isoprenylated flavones, artochamins A-E, and cytotoxic principles from Artocarpus chama
文献类型：期刊论文
| 作者 | Wang, YH ; Hou, AJ; Chen, L; Chen, DF; Sun, HD; Zhao, QS; Bastow, KF; Nakanish, Y; Wang, XH; Lee, KH
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2004-05-01 |
| 卷号 | 67期号:5页码:757-761 |
| 关键词 | Paris-polyphylla Sm Domestic Plants Var Pluriflorum Components Glycosides Rhizomes Constituents Spirostanol Sapogenins Leaves |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/np030467y |
| 通讯作者 | Hou, AJ, Fudan Univ, Sch Pharm, Dept Pharmacognosy, 138 Yi Xue Yuan Rd, Shanghai 200032, Peoples R China |
| 文献子类 | Article |
| 英文摘要 | Five new isoprenylated flavones, artochamins A-E (1-5), together with eight known flavones (6-13), were isolated from the roots of Artocarpus chama. All structures were elucidated by spectroscopic methods. Artonin E (12) showed strong cytotoxicity against 1A9 (ovarian), significant activity against MCF-7 (breast adenocarcinoma), and moderate activity against HCT-8 (ileocecal) and MDA-MB-231 (breast adenocarcinoma) tumor cell lines. Artochamin C (3) was more potent against MCF-7, 1A9, HCT-8, and SK-MEL-2 (melanoma) than A549 (lung carcinoma), KB (epidermoid carcinoma of the nasopharynx), and its drug-resistant (KB-VIN) variant. Artocarpin (6) displayed weak but relatively broad inhibitory effects compared with 3 and 12. |
| 学科主题 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| WOS关键词 | ISOPRENOID-SUBSTITUTED FLAVONOIDS ; TUMOR-CELL LINES ; ROOT BARK ; HETEROPHYLLUS LAMK ; MORACEAE PLANTS ; PRENYLFLAVONES ; CONSTITUENTS ; COMMUNIS ; ALTILIS |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000221804700003 |
| 公开日期 | 2012-03-21 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/4634]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 200032, Peoples R China 2.Acad Sinica, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Yunnan, Peoples R China 3.Univ N Carolina, Sch Pharm, Div Med Chem & Nat Prod, Nat Prod Lab, Chapel Hill, NC 27599 USA |
| 推荐引用方式 GB/T 7714 | Wang, YH,Hou, AJ,Chen, L,et al. New isoprenylated flavones, artochamins A-E, and cytotoxic principles from Artocarpus chama[J]. JOURNAL OF NATURAL PRODUCTS,2004,67(5):757-761. |
| APA | Wang, YH.,Hou, AJ.,Chen, L.,Chen, DF.,Sun, HD.,...&Lee, KH.(2004).New isoprenylated flavones, artochamins A-E, and cytotoxic principles from Artocarpus chama.JOURNAL OF NATURAL PRODUCTS,67(5),757-761. |
| MLA | Wang, YH,et al."New isoprenylated flavones, artochamins A-E, and cytotoxic principles from Artocarpus chama".JOURNAL OF NATURAL PRODUCTS 67.5(2004):757-761. |
入库方式： OAI收割
来源：昆明植物研究所
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