Cytotoxic ent-kauranoids from Isodon leucophyllus
文献类型：期刊论文
| 作者 | Zhao, AH; Xiang, W; Na, Z; Wang, ZY; Lin, ZW; Sun, HD
|
| 刊名 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
 |
| 出版日期 | 2004-06-01 |
| 卷号 | 6期号:2页码:145-150 |
| 关键词 | Isodon Leucophyllus Labiatae Ent-kaurane Diterpenoids Baiyecrystal d Baiyecrystal e Cytotoxic Activities |
| ISSN号 | 1028-6020 |
| DOI | 10.1080/1028602031000147410 |
| 文献子类 | Article |
| 英文摘要 | Two new compounds, baiyecrystals D and E ( 1 , 2 ), together with eight known analogues, xerophilusin B ( 4 ), macrocalin B ( 5 ), oridonin ( 6 ), rosthorin A ( 7 ), lasiocarpanin ( 8 ), rabdoternin A ( 9 ) and phyllostachysin A ( 10 ) and B ( 11 ), were isolated from the aerial parts of Isodon leucophyllus . The structures of 1 and 2 and 4 - 11 were elucidated on the basis of spectroscopic methods, especially the 2D NMR spectral analysis. Compounds 2 , 6 - 8 and 10 were evaluated for their antineoplastic activities in vitro . Among them, lasiocarpanin ( 8 ) showed significant inhibitory activities against K562 and Bcap37 cells, with the IC50 values of 0.13 and 1.26 mug mL(-1) , respectively, which were lower than those of the positive control. |
| 学科主题 | Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| WOS关键词 | DITERPENOIDS ; ELUCIDATION |
| WOS研究方向 | Plant Sciences ; Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000186924600009 |
| 公开日期 | 2012-03-21 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/4656]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China 2.Kunming Med Coll, Dept Pharmacol, Kunming 650031, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, AH,Xiang, W,Na, Z,et al. Cytotoxic ent-kauranoids from Isodon leucophyllus[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2004,6(2):145-150. |
| APA | Zhao, AH,Xiang, W,Na, Z,Wang, ZY,Lin, ZW,&Sun, HD.(2004).Cytotoxic ent-kauranoids from Isodon leucophyllus.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,6(2),145-150. |
| MLA | Zhao, AH,et al."Cytotoxic ent-kauranoids from Isodon leucophyllus".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 6.2(2004):145-150. |
入库方式： OAI收割
来源：昆明植物研究所
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