Two new pregnanone derivatives with strong cytotoxic activity from Pachysandra arillaris
文献类型：期刊论文
| 作者 | Qiu, MH ; Nakamura, N; Min, BS; Hattori, M
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| 刊名 | CHEMISTRY & BIODIVERSITY
 |
| 出版日期 | 2005 |
| 卷号 | 2期号:7页码:866-871 |
| 关键词 | Relative Configuration L-755 Alzheimers-disease 807 Militarinone-a Metabolites Targets |
| ISSN号 | 1612-1872 |
| 通讯作者 | Qiu, MH, Chinese Acad Sci, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Peoples R China |
| 文献子类 | Article |
| 英文摘要 | Two new, bioactive, pregnane-based natural products, pachysanonin (=3 beta,11 alpha,12 beta)-12-acetoxy-3-(dimethylamino)-11-[(3,4-dimethylpent-3-enoyl)oxy]pregnan-20-one; 1) and pachysanone (=(11 alpha,12 beta)-12-acetoxy-11-[(3,4-dimethylpent-3-enoyl)oxy]pregnan-3,20-dion; 2) have been isolated from Pachysandra axillaris. Their structures were determined by spectroscopic methods, and, in the case of 2, by single-crystal X-ray crystallography (Figure). Compound 2 showed significant antitumor activity against Lewis lung carcinoma (LCC) tumor cells, with an IC50 value of 0.020 +/- 0.006 mu g/ml, which is equal or even lower than those of the well-known natural antitumor agents harringtonine (0.02), homoharringtonine (0.15), and adriamycin (0.06 mu g/ml; positive control). |
| 学科主题 | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000231048200003 |
| 公开日期 | 2012-03-21 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/4756]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Peoples R China 2.Toyama Med & Pharmaceut Univ, Res Inst Tradit Sino Japanese Med, Toyama 9300194, Japan |
| 推荐引用方式 GB/T 7714 | Qiu, MH,Nakamura, N,Min, BS,et al. Two new pregnanone derivatives with strong cytotoxic activity from Pachysandra arillaris[J]. CHEMISTRY & BIODIVERSITY,2005,2(7):866-871. |
| APA | Qiu, MH,Nakamura, N,Min, BS,&Hattori, M.(2005).Two new pregnanone derivatives with strong cytotoxic activity from Pachysandra arillaris.CHEMISTRY & BIODIVERSITY,2(7),866-871. |
| MLA | Qiu, MH,et al."Two new pregnanone derivatives with strong cytotoxic activity from Pachysandra arillaris".CHEMISTRY & BIODIVERSITY 2.7(2005):866-871. |
入库方式： OAI收割
来源：昆明植物研究所
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