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  2. 昆明植物研究所
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  4. 植物化学与西部植物资源持续利用国家重点实验室
Lignans with Anti-HIV Activity from Schisandra propinqua var. sinensis

文献类型：期刊论文

作者Li, Xiao-Nian1,6; Pu, Jian-Xin1; Du, Xue1; Yang, Liu-Meng2,3; An, Hui-Mei4,5; Lei, Chun1; He, Fei1; Luo, Xiao1; Zheng, Yong-Tang2,3; Lu, Yang4,5
刊名JOURNAL OF NATURAL PRODUCTS
出版日期2009-06-01
卷号72期号:6页码:1133-1141
ISSN号0163-3864
DOI10.1021/np900123z
文献子类Article
英文摘要Fourteen new lignans, tiegusanins A-N (1-14), together with 13 known compounds were isolated from the aerial parts of Schisandra propinqua var. sinensis. The structures and absolute configurations of 1-13 were established using a combination of spectroscopic techniques. Compound 14 was obtained as a racemate. When evaluated for inhibitory activity against HIV-1, tiegusanin G (7) showed anti-HIV-1 activity with an EC(50) value of 7.9 mu M and a therapeutic index (TI) of more than 25.
学科主题Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS关键词SCHIZANDRA-CHINENSIS BAILL ; DIBENZOCYCLOOCTADIENE LIGNANS ; KADSURA INTERIOR ; TRITERPENE DILACTONES ; SHENNONGJIA-DISTRICT ; ABSOLUTE STRUCTURE ; MACHILUS-JAPONICA ; GOMISIN-G ; CONSTITUENTS ; LONGIPEDUNCULATA
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000267432600028
资助机构NSFC [30830115, 20802082]; Major State Basic Research Development Program of China [2009CB522303, 2009CB940900]; Chinese Academy of Sciences [KSCX1-YW-R-24]; Yong Academic and Technical Leader Rising Foundation of Yunnan Province [2006PY01-47]; Natural Science Foundation of Yunnan Province [2005XY04, 2006B0042Q]
公开日期2012-03-21
源URL[http://ir.kib.ac.cn:8080/handle/151853/4800]  
专题昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mechanisms, Kunming 650223, Yunnan, Peoples R China
3.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Yunnan, Peoples R China
4.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
5.Peking Union Med Coll, Beijing 100050, Peoples R China
6.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式
GB/T 7714		 Li, Xiao-Nian,Pu, Jian-Xin,Du, Xue,et al. Lignans with Anti-HIV Activity from Schisandra propinqua var. sinensis[J]. JOURNAL OF NATURAL PRODUCTS,2009,72(6):1133-1141.
APA Li, Xiao-Nian.,Pu, Jian-Xin.,Du, Xue.,Yang, Liu-Meng.,An, Hui-Mei.,...&Sun, Han-Dong.(2009).Lignans with Anti-HIV Activity from Schisandra propinqua var. sinensis.JOURNAL OF NATURAL PRODUCTS,72(6),1133-1141.
MLA Li, Xiao-Nian,et al."Lignans with Anti-HIV Activity from Schisandra propinqua var. sinensis".JOURNAL OF NATURAL PRODUCTS 72.6(2009):1133-1141.

入库方式： OAI收割

来源：昆明植物研究所

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