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Approach to the Biosynthesis of Atisine-Type Diterpenoid Alkaloids

文献类型：期刊论文

作者Zhao, Pei-Ji; Gao, Suo; Fan, Li-Ming; Nie, Jing-Lei; He, Hong-Ping; Zeng, Ying; Shen, Yue-Mao; Hao, Xiao-Jiang
刊名JOURNAL OF NATURAL PRODUCTS
出版日期2009-04-01
卷号72期号:4页码:645-649
ISSN号0163-3864
关键词Rubescens Var.-taihangensis Rabdosia-pseudo-irrorata Kaurene Diterpenoids
DOI10.1021/np800657j
文献子类Article
英文摘要To determine the biosynthesis pathway of the atisine-type diterpenoid alkaloids spiramines A/B and C/D, feeding experiments in in vitro Cultured plantlets; and enzymatic transformations in cell-free extracts were performed in combination with LCMS and tandem MS analyses. L-[2-(13)C,(15)N]Serine was used in the feeding experiments and enzymatic transformations, and the diterpene spiraminol was identified as it biosynthetic precursor of spiramine alkaloids. The LCMS and tandem MS spectra of the extracts from these experiments indicated that L-[2-(13)C,(15)N]serine was incorporated into spiramines A/B and C/D. The labeled reaction products show that L-serine is the one possible nitrogen source involved in the biosynthesis of atisine-type DAs.
学科主题Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS关键词ACID ; CULTURES ; SERINE
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000265530000008
资助机构National Natural Science Foundation of China [30070087]
公开日期2012-03-21
源URL[http://ir.kib.ac.cn:8080/handle/151853/4816]  
专题昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
推荐引用方式
GB/T 7714		 Zhao, Pei-Ji,Gao, Suo,Fan, Li-Ming,et al. Approach to the Biosynthesis of Atisine-Type Diterpenoid Alkaloids[J]. JOURNAL OF NATURAL PRODUCTS,2009,72(4):645-649.
APA Zhao, Pei-Ji.,Gao, Suo.,Fan, Li-Ming.,Nie, Jing-Lei.,He, Hong-Ping.,...&Hao, Xiao-Jiang.(2009).Approach to the Biosynthesis of Atisine-Type Diterpenoid Alkaloids.JOURNAL OF NATURAL PRODUCTS,72(4),645-649.
MLA Zhao, Pei-Ji,et al."Approach to the Biosynthesis of Atisine-Type Diterpenoid Alkaloids".JOURNAL OF NATURAL PRODUCTS 72.4(2009):645-649.

入库方式： OAI收割

来源：昆明植物研究所

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