中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Synthesis and Bioactivity Evaluation of 3-Hydroxy-3-(phenylethynyl)indol-2-one Analogues

文献类型:期刊论文

作者Chen, Gang1,2; Wang, Ye3,4; Gao, Suo1; He, Hong-Ping1; Li, Shun-Lin1; Zhang, Jian-Xin3,4; Ding, Jian5; Hao, Xiao-Jiang1,3,4
刊名JOURNAL OF HETEROCYCLIC CHEMISTRY
出版日期2009-03-01
卷号46期号:2页码:217-220
关键词Anti-hiv Activity Spin Coupling-constants Kalata B1 Plant Cyclotides Oldenlandia-affinis Spatial Structure Circular Protein Cyclic Peptide Membrane Interaction Structural Motif
ISSN号0022-152X
DOI10.1002/jhet.58
文献子类Article
英文摘要

A series of propargylic alcohol was synthesized by the addition of phenylacetylene to isatin and its N-substituted derivatives for the first time. This reaction involves activation of zinc reagent via coordination with carbonyl substrates that behave "ligand like." The bioactivities on protective effect on the apoplosis of PC12 cells induced by H2O2 and cytotoxicity against lung cancer A549 and P388 cell line of these compounds were investigated, and several compounds showed potent activities.

学科主题Chemistry, Organic
WOS关键词ISATIN
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000265992700014
公开日期2012-03-21
源URL[http://ir.kib.ac.cn:8080/handle/151853/4820]  
专题昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Xian Shiyou Univ, Coll Chem & Chem Engn, Xian 710065, Shaanxi, Peoples R China
3.Chinese Acad Sci, Guiyang 550002, Peoples R China
4.Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Peoples R China
5.Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714
Chen, Gang,Wang, Ye,Gao, Suo,et al. Synthesis and Bioactivity Evaluation of 3-Hydroxy-3-(phenylethynyl)indol-2-one Analogues[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY,2009,46(2):217-220.
APA Chen, Gang.,Wang, Ye.,Gao, Suo.,He, Hong-Ping.,Li, Shun-Lin.,...&Hao, Xiao-Jiang.(2009).Synthesis and Bioactivity Evaluation of 3-Hydroxy-3-(phenylethynyl)indol-2-one Analogues.JOURNAL OF HETEROCYCLIC CHEMISTRY,46(2),217-220.
MLA Chen, Gang,et al."Synthesis and Bioactivity Evaluation of 3-Hydroxy-3-(phenylethynyl)indol-2-one Analogues".JOURNAL OF HETEROCYCLIC CHEMISTRY 46.2(2009):217-220.

入库方式: OAI收割

来源:昆明植物研究所

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