Synthesis and Bioactivity Evaluation of 3-Hydroxy-3-(phenylethynyl)indol-2-one Analogues
文献类型:期刊论文
作者 | Chen, Gang1,2; Wang, Ye3,4; Gao, Suo1; He, Hong-Ping1; Li, Shun-Lin1; Zhang, Jian-Xin3,4; Ding, Jian5; Hao, Xiao-Jiang1,3,4![]() |
刊名 | JOURNAL OF HETEROCYCLIC CHEMISTRY
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出版日期 | 2009-03-01 |
卷号 | 46期号:2页码:217-220 |
关键词 | Anti-hiv Activity Spin Coupling-constants Kalata B1 Plant Cyclotides Oldenlandia-affinis Spatial Structure Circular Protein Cyclic Peptide Membrane Interaction Structural Motif |
ISSN号 | 0022-152X |
DOI | 10.1002/jhet.58 |
文献子类 | Article |
英文摘要 | A series of propargylic alcohol was synthesized by the addition of phenylacetylene to isatin and its N-substituted derivatives for the first time. This reaction involves activation of zinc reagent via coordination with carbonyl substrates that behave "ligand like." The bioactivities on protective effect on the apoplosis of PC12 cells induced by H2O2 and cytotoxicity against lung cancer A549 and P388 cell line of these compounds were investigated, and several compounds showed potent activities. |
学科主题 | Chemistry, Organic |
WOS关键词 | ISATIN |
WOS研究方向 | Chemistry |
语种 | 英语 |
WOS记录号 | WOS:000265992700014 |
公开日期 | 2012-03-21 |
源URL | [http://ir.kib.ac.cn:8080/handle/151853/4820] ![]() |
专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Xian Shiyou Univ, Coll Chem & Chem Engn, Xian 710065, Shaanxi, Peoples R China 3.Chinese Acad Sci, Guiyang 550002, Peoples R China 4.Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Peoples R China 5.Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China |
推荐引用方式 GB/T 7714 | Chen, Gang,Wang, Ye,Gao, Suo,et al. Synthesis and Bioactivity Evaluation of 3-Hydroxy-3-(phenylethynyl)indol-2-one Analogues[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY,2009,46(2):217-220. |
APA | Chen, Gang.,Wang, Ye.,Gao, Suo.,He, Hong-Ping.,Li, Shun-Lin.,...&Hao, Xiao-Jiang.(2009).Synthesis and Bioactivity Evaluation of 3-Hydroxy-3-(phenylethynyl)indol-2-one Analogues.JOURNAL OF HETEROCYCLIC CHEMISTRY,46(2),217-220. |
MLA | Chen, Gang,et al."Synthesis and Bioactivity Evaluation of 3-Hydroxy-3-(phenylethynyl)indol-2-one Analogues".JOURNAL OF HETEROCYCLIC CHEMISTRY 46.2(2009):217-220. |
入库方式: OAI收割
来源:昆明植物研究所
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