Potent alpha-glucosidase inhibitors from the roots of Panax japonicus C. A. Meyer var. major
文献类型：期刊论文
| 作者 | Chan, Hsiu-Hui1; Sun, Han-Dong2 ; Reddy, Mopur Vijaya Bhaskar1; Wu, Tian-Shung1,3
|
| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2010-08-01 |
| 卷号 | 71期号:11-12页码:1360-1364 |
| 关键词 | Araliaceae PA.A. JA.oniC.s C. A. Meyer vA.. mA.or Zu-tziseng Polyacetylene Acarbose Alpha-glucosidase Inhibitors |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2010.04.013 |
| 文献子类 | Article |
| 英文摘要 | Bioassay-guided fractionation of the CHCl(3) soluble portion of the roots of Panax japonicus C. A. Meyer var. major afforded an active fraction with inhibitory activity against baker's yeast alpha-glucosidase with an IC(50) value 1.02 mg/mL. Furthermore, the active fraction isolated contained three previously unreported polyacetylenes, designated panaxjapynes A-C, together with 11 other compounds, including four polyacetylenes, five phenolic compounds, a sesquiterpenoid, and a sterol glucoside. The structures of the compounds were elucidated by spectroscopic and chemical methods. Compared with the control acarbose (IC(50) 677.97 mu M), six compounds were shown to be more potent alpha-glucosidase inhibitors with IC(50) values in the range 22.21-217.68 mu M. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Plant Sciences |
| WOS关键词 | ACTIVATES ESTROGEN-RECEPTOR ; CHEMICAL-CONSTITUENTS ; ABSOLUTE STRUCTURE ; ACID-DERIVATIVES ; GINSENG ; CELLS ; POLYACETYLENES ; FALCARINOL |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000280321000018 |
| 资助机构 | National Science Council of Republic of China |
| 公开日期 | 2012-03-21 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/4866]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Natl Cheng Kung Univ, Dept Chem, Tainan 70101, Taiwan 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 3.China Med Univ, Dept Pharm, Taichung 40402, Taiwan |
| 推荐引用方式 GB/T 7714 | Chan, Hsiu-Hui,Sun, Han-Dong,Reddy, Mopur Vijaya Bhaskar,et al. Potent alpha-glucosidase inhibitors from the roots of Panax japonicus C. A. Meyer var. major[J]. PHYTOCHEMISTRY,2010,71(11-12):1360-1364. |
| APA | Chan, Hsiu-Hui,Sun, Han-Dong,Reddy, Mopur Vijaya Bhaskar,&Wu, Tian-Shung.(2010).Potent alpha-glucosidase inhibitors from the roots of Panax japonicus C. A. Meyer var. major.PHYTOCHEMISTRY,71(11-12),1360-1364. |
| MLA | Chan, Hsiu-Hui,et al."Potent alpha-glucosidase inhibitors from the roots of Panax japonicus C. A. Meyer var. major".PHYTOCHEMISTRY 71.11-12(2010):1360-1364. |
入库方式： OAI收割
来源：昆明植物研究所
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