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Cardiac Glycosides from Antiaris toxicaria with Potent Cardiotonic Activity

文献类型：期刊论文

作者Shi, Li-Shian1; Liao, Yu-Ren1; Su, Ming-Jai2; Lee, An-Sheng2; Kuo, Ping-Chung1; Damu, Amooru G.1; Kuo, Sheng-Chu3; Sun, Han-Dong5; Lee, Kuo-Hsiung6; Wu, Tian-Shung1,4
刊名JOURNAL OF NATURAL PRODUCTS
出版日期2010-07-01
卷号73期号:7页码:1214-1222
关键词Alstonia-scholaris Leaves Culture Pichon
ISSN号0163-3864
DOI10.1021/np9005212
通讯作者Wu, TS, Natl Cheng Kung Univ, Dept Chem, Tainan 70101, Taiwan
文献子类Article
英文摘要An ethanolic extract of Antiaris toxicaria trunk hark showed potent in vitro cardiotonic effect on isolated guinea pig atria. Bioassay-guided fractionation of the extract led to identification of nine new cardiac glycosides (1-9, named antiarosides A-1), antiarotoxinin A (10), and 18 known compounds. Their structures were established using MS and NMR spectroscopic studies, including homonuclear and heteronuclear correlation experiments. The ability of these cardiotonic compounds to produce positive inotropic action and their safety indexes were examined in comparison with those of ouabain, a classical inhibitor of Na(+)/K(+)-ATPase. Malayoside (23) was nearly equipotent and had a similar safety index to ouabain in guinea pig atria. However, the maximal positive inotropic effect and safety index of 23 in papillary muscle were better than those of ouabain. An electrophysiological recording showed that 23 inhibited the sod urn pump current in a concentration-dependent manlier.
学科主题Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS关键词GLYKOSIDE UND AGLYKONE ; DART POISONS ; LESCH ; ARROW
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000280140500005
资助机构National Science Council, Taiwan, Republic of China ; NIH [CA-17625]
公开日期2012-03-21
源URL[http://ir.kib.ac.cn:8080/handle/151853/4886]  
专题昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Natl Cheng Kung Univ, Dept Chem, Tainan 70101, Taiwan
2.Natl Taiwan Univ, Coll Med, Inst Pharmacol, Taipei, Taiwan
3.China Med Univ, Grad Inst Pharmaceut Chem, Taichung 401, Taiwan
4.China Med Univ, Dept Pharm, Taichung 401, Taiwan
5.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
6.Univ N Carolina, Nat Prod Res Labs, UNC Eshelman Sch Pharm, Chapel Hill, NC 27599 USA
推荐引用方式
GB/T 7714		 Shi, Li-Shian,Liao, Yu-Ren,Su, Ming-Jai,et al. Cardiac Glycosides from Antiaris toxicaria with Potent Cardiotonic Activity[J]. JOURNAL OF NATURAL PRODUCTS,2010,73(7):1214-1222.
APA Shi, Li-Shian.,Liao, Yu-Ren.,Su, Ming-Jai.,Lee, An-Sheng.,Kuo, Ping-Chung.,...&Wu, Tian-Shung.(2010).Cardiac Glycosides from Antiaris toxicaria with Potent Cardiotonic Activity.JOURNAL OF NATURAL PRODUCTS,73(7),1214-1222.
MLA Shi, Li-Shian,et al."Cardiac Glycosides from Antiaris toxicaria with Potent Cardiotonic Activity".JOURNAL OF NATURAL PRODUCTS 73.7(2010):1214-1222.

入库方式： OAI收割

来源：昆明植物研究所

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