Cytotoxic Chemical Constituents from the Roots of Cimicifuga fetida
文献类型：期刊论文
| 作者 | Nian, Yin1,2 ; Zhang, Yan-Li3; Chen, Jian-Chao1; Lu, Lu1,2; Qiu, Ming-Hua1; Qing, Chen3
|
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2010-02-01 |
| 卷号 | 73期号:2页码:93-98 |
| 关键词 | Cinerascens Tetranortriterpenoids |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/np9003855 |
| 文献子类 | Article |
| 英文摘要 | Seven new 9,19-cycloartane triterpene glycosides. 25-O-acetylcimigenol-3-O-[2'-O-(E)-2-butenoyl]-beta-D-xylopyranoside (1), 25-O-acetylcimigenol-3-O-[4'-O-(E)-2-butenoyl]-beta-D-xylopyranoside (2), 25-O-acetylcimigenol-3-O-[3'-O-acetyl]-beta-D-xylopyranoside (3), 25-O-acetylcimigenol-3-O-[4'-O-acetyl]-beta-D-xylopyranoside (4), 25-O-acetyl-12 beta-acetoxycimingenol-3-O-beta-D-xylopyranoside (5), 3'-O-acetylactein (6). and 3'-O-acetyl-23-epi-26-deoxyactein (7), together with eight known compounds (8-15), were isolated from the roots of Cimicifuga fetida. Their structures were established by spectroscopic and chemical methods. Most of these compounds Showed more selective and higher cytotoxicity against the human HepG2 cell line than against the MCF7, HT29. and MKN28 cell lines. compounds 2, 3, and 7 exhibited significant cytotoxicity against HepG2 cells, with IC(50) values of 1.29, 0.71, and 1.41 mu M, respectively. |
| 学科主题 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| WOS关键词 | CYCLOARTANE TRITERPENE SAPONINS ; SEQUENCE VARIATION ; BLACK COHOSH ; FOETIDA L ; GLYCOSIDES ; RACEMOSA ; ACTAEA ; PROLIFERATION ; RANUNCULACEAE ; PHYLOGENY |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000274803600001 |
| 资助机构 | Foundation of the Key State Laboratory of Phytochemistry [P2008-ZZ05]; National Natural Science Foundation of China [30772636]; National Science Foundation of Yunnan Province [2005C0010Z] |
| 公开日期 | 2012-03-21 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/4898]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Kunming Med Coll, Yunnan Key Lab Pharmacol Nat Prod Res, Kunming 650031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Nian, Yin,Zhang, Yan-Li,Chen, Jian-Chao,et al. Cytotoxic Chemical Constituents from the Roots of Cimicifuga fetida[J]. JOURNAL OF NATURAL PRODUCTS,2010,73(2):93-98. |
| APA | Nian, Yin,Zhang, Yan-Li,Chen, Jian-Chao,Lu, Lu,Qiu, Ming-Hua,&Qing, Chen.(2010).Cytotoxic Chemical Constituents from the Roots of Cimicifuga fetida.JOURNAL OF NATURAL PRODUCTS,73(2),93-98. |
| MLA | Nian, Yin,et al."Cytotoxic Chemical Constituents from the Roots of Cimicifuga fetida".JOURNAL OF NATURAL PRODUCTS 73.2(2010):93-98. |
入库方式： OAI收割
来源：昆明植物研究所
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