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Anti-Tobacco Mosaic Virus (TMV) Quassinoids from Brucea javanica (L.) Merr.

文献类型：期刊论文

作者Yan, Xiao-Hui1,2; Chen, Jia1,2; Di, Ying-Tong1; Fang, Xin1; Dong, Jia-Hong3; Sang, Peng3; Wang, Yue-Hu1; He, Hong-Ping1; Zhang, Zhong-Kai3; Hao, Xiao-Jiang1
刊名JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
出版日期2010-02-10
卷号58期号:3页码:1572-1577
关键词Tobacco Mosaic Virus (Tmv) Brucea Javanica (L.) Merr. Quassinoids Structure-activity Relationship (Sar)
ISSN号0021-8561
DOI10.1021/jf903434h
文献子类Article
英文摘要Two new quassinoids, javanicolide E (1) and javanicolide F (2), along with fifteen known C-20 quassinoids were isolated from the seeds of Brucea javanica (L.) Merr. The antitobacco, mosaic virus (TMV) activity of these quassinoids was screened by the conventional half-leaf and leaf-disk method along with Western blot analysis. All of the seventeen quassinoids showed potent anti-TMV activity. Among them, eight compounds, brusatol (3), bruceine B (4), bruceoside B (5), yadanzioside 1 (6), yaclanzioside L (7), bruceine D (8), yadanziolide A (9), and aglycone of yadanziolide D (17), showed strong antiviral activities, with IC(50) values in the range of 3.42-5.66 mu M, and were much more effective than the positive control, ningnanmycin (IC(50) = 117.3 mu M). The antiviral structure-activity relationships of quassinoids against TMV were also discussed.
学科主题Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
WOS关键词INHIBITORY-ACTIVITY ; BITTER PRINCIPLES ; YADANZIOLIDE-A ; SEEDS ; CONSTITUENTS ; PURIFICATION ; RESISTANCE
WOS研究方向Agriculture ; Chemistry ; Food Science & Technology
语种英语
WOS记录号WOS:000274269000028
资助机构Knowledge Innovation Program of the Chinese Academy of Sciences [KSCXR-YW-N-008]; Ministry of Science and Technology [2009CB522303]; 863 program or State Hightech Development Plan [2007AA021505]
公开日期2012-03-21
源URL[http://ir.kib.ac.cn:8080/handle/151853/4944]  
专题昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Yunnan Acad Agr Sci, Kunming 650023, Yunnan, Peoples R China
推荐引用方式
GB/T 7714		 Yan, Xiao-Hui,Chen, Jia,Di, Ying-Tong,et al. Anti-Tobacco Mosaic Virus (TMV) Quassinoids from Brucea javanica (L.) Merr.[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2010,58(3):1572-1577.
APA Yan, Xiao-Hui.,Chen, Jia.,Di, Ying-Tong.,Fang, Xin.,Dong, Jia-Hong.,...&Hao, Xiao-Jiang.(2010).Anti-Tobacco Mosaic Virus (TMV) Quassinoids from Brucea javanica (L.) Merr..JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,58(3),1572-1577.
MLA Yan, Xiao-Hui,et al."Anti-Tobacco Mosaic Virus (TMV) Quassinoids from Brucea javanica (L.) Merr.".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 58.3(2010):1572-1577.

入库方式： OAI收割

来源：昆明植物研究所

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