Bioactive flavones and biflavones from Selaginella moellendorffii Hieron
文献类型：期刊论文
| 作者 | Cao, Yuan1; Tan, Nin-Hua3; Chen, Ji-Jun3 ; Zeng, Guang-Zhi3; Ma, Yun-Bao3; Wu, Yong-Ping2; Yan, He3; Yang, Jie1; Lu, Lai-Feng1; Wang, Qiang1
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2010-06-01 |
| 卷号 | 81期号:4页码:253-258 |
| 关键词 | Selaginella Moellendorffii Selaginellacea Flavone Biflavone Anti-hbv Activity Cytotoxicity |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2009.09.007 |
| 文献子类 | Article |
| 英文摘要 | Three new flavones named 5-carboxymethyl-4',7-dihydroxyflavone (1), its ethyl ester (2) and butyl ester (3) were isolated from the herb Selaginella moellendorffii Hieron., together with ten known compounds. Their structures were elucidated on the basis of spectroscopic and chemical analysis. Selected compounds were evaluated for their anti-HBV and cytotoxic activity. Among them, compounds 2 and 3 displayed inhibitory activity in vitro on hepatitis B virus (HBV) surface antigen (HBsAg) secretion of the Hep G2.2.15 cell line with IC(50) values of 0.17 mg/ml and 0.46 mg/ml, and on HBV e antigen (HBeAg) secretion with IC(50) values of 0.42 mg/ml and 0.42 mg/ml, respectively. Compounds 7.8. 10 and 12 exhibited selective cytotoxicity against the three human cancer cell lines tested. (C) 2009 Elsevier By. All rights reserved. |
| 学科主题 | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| WOS关键词 | CYTOTOXIC BIFLAVONOIDS ; DOEDERLEINII ; DELICATULA |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000277699400006 |
| 公开日期 | 2012-03-21 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/4974]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.China Pharmaceut Univ, Dept Chinese Mat Med Anal, Nanjing 210009, Peoples R China 2.Jiangsu Prov Inst Mat Med, Nanjing 210009, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cao, Yuan,Tan, Nin-Hua,Chen, Ji-Jun,et al. Bioactive flavones and biflavones from Selaginella moellendorffii Hieron[J]. FITOTERAPIA,2010,81(4):253-258. |
| APA | Cao, Yuan.,Tan, Nin-Hua.,Chen, Ji-Jun.,Zeng, Guang-Zhi.,Ma, Yun-Bao.,...&Wang, Qiang.(2010).Bioactive flavones and biflavones from Selaginella moellendorffii Hieron.FITOTERAPIA,81(4),253-258. |
| MLA | Cao, Yuan,et al."Bioactive flavones and biflavones from Selaginella moellendorffii Hieron".FITOTERAPIA 81.4(2010):253-258. |
入库方式： OAI收割
来源：昆明植物研究所
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