Antiviral activity and possible mechanisms of action of pentagalloylglucose (PGG) against influenza A virus
文献类型：期刊论文
| 作者 | Liu, Ge1; Xiong, Sheng1,2; Xiang, Yang-Fei2; Guo, Chao-Wan1; Ge, Feng1; Yang, Chong-Ren3; Zhang, Ying-Jun3 ; Wang, Yi-Fei2; Kitazato, Kaio1
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| 刊名 | ARCHIVES OF VIROLOGY
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| 出版日期 | 2011-08-01 |
| 卷号 | 156期号:8页码:1359-1369 |
| ISSN号 | 0304-8608 |
| 关键词 | H1n1 Virus 1 Kappa-b 2 Inhibition 3 Infection 4 6-penta-o-galloyl-beta-d-glucose Cells Plant H5n1 Replication Propagation |
| DOI | 10.1007/s00705-011-0989-9 |
| 通讯作者 | kkholi@nagasaki-u.ac.jp |
| 文献子类 | Article |
| 英文摘要 | Influenza A virus (IAV) infection is a major public health threat leading to significant morbidity and mortality. The emergence of drug-resistant virus strains highlights the urgent need to develop novel antiviral drugs with alternative modes of action. Pentagalloylglucose (PGG), a naturally occurring polyphenolic compound, possesses a broad spectrum of biological activities. In this study, we found that PGG has anti-influenza-virus activity, and investigated its possible mechanism(s) of action in vitro. Both pre-incubation of virus prior to infection and post-exposure of infected cells with PGG significantly inhibited virus yields. Influenza-virus-induced hemagglutination of chicken red blood cells was inhibited by PGG treatment, suggesting that PGG can inhibit IAV infection by interacting with the viral hemagglutinin. PGG did not affect viral protein synthesis or nuclear transport of viral nucleoprotein (NP) but greatly reduced plasma membrane accumulation of NP protein at the late stage of the replication cycle. Furthermore, PGG significantly reduced virus budding and progeny virus release from infected cells. This study revealed for the first time that PGG can inhibit IAV replication with a dual mode of action and offers new insights into its underlying mechanisms of antiviral action. |
| 学科主题 | Virology |
| WOS关键词 | H1N1 VIRUS ; KAPPA-B ; INHIBITION ; INFECTION ; 1,2,3,4,6-PENTA-O-GALLOYL-BETA-D-GLUCOSE ; CELLS ; PLANT ; H5N1 ; REPLICATION ; PROPAGATION |
| WOS研究方向 | Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000293236100006 |
| 资助机构 | Tokyo Biochemical Research Foundation; National Science Foundation of China[U0632010]; State Key Laboratory of Phytochemistry and Plant Resources in West China; Kunming Institute of Botany; Chinese Academy of Sciences[P2008-KF07, P2008-ZZ08] |
| 公开日期 | 2012-03-16 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/3930]  |
| 专题 | 昆明植物研究所_中国科学院东亚植物多样性与生物地理学重点实验室 |
| 作者单位 | 1.Nagasaki Univ, Grad Sch Biomed Sci, Div Mol Pharmacol Infect agents, Dept Mol Microbiol & Immunol, Nagasaki 8528521, Japan 2.Jinan Univ, Biomed R&D Ctr, Natl Engn Res Ctr Genet Med, Guangdong Prov Key Lab Bioengn Med, Guangzhou 510632, Guangdong, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Ge,Xiong, Sheng,Xiang, Yang-Fei,et al. Antiviral activity and possible mechanisms of action of pentagalloylglucose (PGG) against influenza A virus[J]. ARCHIVES OF VIROLOGY,2011,156(8):1359-1369. |
| APA | Liu, Ge.,Xiong, Sheng.,Xiang, Yang-Fei.,Guo, Chao-Wan.,Ge, Feng.,...&Kitazato, Kaio.(2011).Antiviral activity and possible mechanisms of action of pentagalloylglucose (PGG) against influenza A virus.ARCHIVES OF VIROLOGY,156(8),1359-1369. |
| MLA | Liu, Ge,et al."Antiviral activity and possible mechanisms of action of pentagalloylglucose (PGG) against influenza A virus".ARCHIVES OF VIROLOGY 156.8(2011):1359-1369. |
入库方式： OAI收割
来源：昆明植物研究所
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