Small Compound 6-O-Angeloylplenolin Induces Mitotic Arrest and Exhibits Therapeutic Potentials in Multiple Myeloma
文献类型：期刊论文
| 作者 | Liu, Ying1,2,3; Chen, Xiao-Qin4; Liang, Heng-Xing5; Zhang, Feng-Xiang1,2; Zhang, Bo1,2; Jin, Jie6; Chen, Yong-Long1,2; Cheng, Yong-Xian5; Zhou, Guang-Biao1,2 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2011-07-06 |
| 卷号 | 6期号:7页码:e21930 |
| 关键词 | Nf-kappa-b Cell-cycle Control Overcomes Drug-resistance Centipeda-minima Antitumor-activity Kinase-activity Human Cancer In-vitro Activation Expression |
| ISSN号 | 1932-6203 |
| DOI | 10.1371/journal.pone.0021930 |
| 通讯作者 | yxcheng@mail.kib.ac.cn ; gbzhou@ioz.ac.cn |
| 文献子类 | Article |
| 英文摘要 | Background: Multiple myeloma (MM) is a disease of cell cycle dysregulation while cell cycle modulation can be a target for MM therapy. In this study we investigated the effects and mechanisms of action of a sesquiterpene lactone 6-O-angeloylplenolin (6-OAP) on MM cells. |
| 学科主题 | Biology |
| WOS关键词 | NF-KAPPA-B ; CELL-CYCLE CONTROL ; OVERCOMES DRUG-RESISTANCE ; CENTIPEDA-MINIMA ; ANTITUMOR-ACTIVITY ; KINASE-ACTIVITY ; HUMAN CANCER ; IN-VITRO ; ACTIVATION ; EXPRESSION |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000292632000037 |
| 资助机构 | National Key Program for Basic Research (973)[2010CB529201]; CAS[KSCX1-YW-R-26, KSCX2-YW-R-235]; National Natural Science Foundation of China[81071930, 30871110]; National Major Scientific and Technological Program for Drug Discovery[2009ZX09103-101]; Natural Science Foundation of Yunnan[2006B0041Q]; Talent Scholarship for the Youth of Yunnan[2007PY01-48] |
| 公开日期 | 2012-03-16 |
| 源URL | [http://ir.kib.ac.cn:8080/handle/151853/3966]  |
| 专题 | 昆明植物研究所_中国科学院东亚植物多样性与生物地理学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Zool, Guangzhou Inst Biomed & Hlth, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Beijing, Peoples R China 3.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Peoples R China 4.Sun Yat Sen Univ, Canc Hosp, Dept Hematol, Guangzhou 510275, Guangdong, Peoples R China 5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming, Peoples R China 6.Zhejiang Univ, Coll Med, Affiliated Hosp 1, Dept Hematol, Hangzhou 310003, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Ying,Chen, Xiao-Qin,Liang, Heng-Xing,et al. Small Compound 6-O-Angeloylplenolin Induces Mitotic Arrest and Exhibits Therapeutic Potentials in Multiple Myeloma[J]. PLOS ONE,2011,6(7):e21930. |
| APA | Liu, Ying.,Chen, Xiao-Qin.,Liang, Heng-Xing.,Zhang, Feng-Xiang.,Zhang, Bo.,...&Zhou, Guang-Biao.(2011).Small Compound 6-O-Angeloylplenolin Induces Mitotic Arrest and Exhibits Therapeutic Potentials in Multiple Myeloma.PLOS ONE,6(7),e21930. |
| MLA | Liu, Ying,et al."Small Compound 6-O-Angeloylplenolin Induces Mitotic Arrest and Exhibits Therapeutic Potentials in Multiple Myeloma".PLOS ONE 6.7(2011):e21930. |
入库方式： OAI收割
来源：昆明植物研究所
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