Structurally Diverse Diterpenoids from lsodon scoparius and Their Bioactivity
文献类型：期刊论文
| 作者 | Jiang, Hua-Yi1,2,3,4; Wang, Wei-Guang1,2; Tang, Jian-Wei1,2; Liu, Miao1,2; Li, Xing-Ren1,2; Hu, Kun1,2 ; Du, Xue1,2; Li, Xiao-Nian1,2; Zhang, Hong-Bin4; Pu, Jian-Xin1,2
|
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2017-07-01 |
| 卷号 | 80期号:7页码:2026-2036 |
| ISSN号 | 0163-3864 |
| 关键词 | Ent-kaurane Diterpenoids Isodon-scoparius Cytotoxic Diterpenoids Abietane Diterpenoids Eriocalyxin-b Derivatives Laxiflora Growth |
| DOI | 10.1021/acs.jnatprod.7b00163 |
| 英文摘要 | Fourteen new diterpenoids (1-14) based on four skeletal types and two known analogues (15 and 16) were isolated from the aerial parts of Isodon scoparius. Compound 2 is the first ent-kaurane diterpenoid featuring a 1,11-ether bridge, and the structures of these new compounds were established mainly by NMR and MS methods. The absolute configurations of 1 and 5 and the relative configuration of 3 were determined using single-crystal X-ray diffraction. The absolute configuration of 14 was determined by comparison of the experimental and calculated electronic circular dichroism spectra. Compounds 1, 4, and 15 were active against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480), and they also inhibited NO production in LPS-stimulated RAW264.7 cells, with IC50 values of 1.0, 3.1, and 1.8 mu M, respectively. |
| 学科主题 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000406818300009 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/54947]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ, Kunming 650091, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Hua-Yi,Wang, Wei-Guang,Tang, Jian-Wei,et al. Structurally Diverse Diterpenoids from lsodon scoparius and Their Bioactivity[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(7):2026-2036. |
| APA | Jiang, Hua-Yi.,Wang, Wei-Guang.,Tang, Jian-Wei.,Liu, Miao.,Li, Xing-Ren.,...&Sun, Han-Dong.(2017).Structurally Diverse Diterpenoids from lsodon scoparius and Their Bioactivity.JOURNAL OF NATURAL PRODUCTS,80(7),2026-2036. |
| MLA | Jiang, Hua-Yi,et al."Structurally Diverse Diterpenoids from lsodon scoparius and Their Bioactivity".JOURNAL OF NATURAL PRODUCTS 80.7(2017):2026-2036. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。