A biomimetic semisynthesis enables structural elucidation of selaginellin U: a tautomeric cyclic alkynylphenol from Selaginella tamariscina
文献类型：期刊论文
| 作者 | Zhu, Qin-Feng1,2; Bao, Ying1,2; Zhang, Zhi-Jun1,2; Su, Jia1; Shao, Li-Dong1; Zhao, Qin-Shi1
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| 刊名 | ROYAL SOCIETY OPEN SCIENCE
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| 出版日期 | 2017-07-01 |
| 卷号 | 4期号:7页码:170352 |
| 关键词 | Biomimetic Semisynthesis Structural Elucidation Selaginellins Alkynylphenol Selaginella Tamariscina |
| ISSN号 | 2054-5703 |
| DOI | 10.1098/rsos.170352 |
| 英文摘要 | Two new lactone-containing selaginellins T and U (1 and 2) together with eleven known selaginellin derivatives (3 and 7-16) were isolated from the whole plant of Selaginella tamariscina. The structure of tautomeric selaginellin U along with its biogenetic pathway was confirmed and proposed by a cross-validation of the semisynthesis of compound 4 from selaginellin (3) and derivation from 2 to 4. Additionally, compounds 3, 13 and 16 exhibited good inhibitory activities against beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) with IC50 values of 81.17, 51.13 and 48.89 mu M, respectively. |
| 学科主题 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000406670000033 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/54948]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Qin-Feng,Bao, Ying,Zhang, Zhi-Jun,et al. A biomimetic semisynthesis enables structural elucidation of selaginellin U: a tautomeric cyclic alkynylphenol from Selaginella tamariscina[J]. ROYAL SOCIETY OPEN SCIENCE,2017,4(7):170352. |
| APA | Zhu, Qin-Feng,Bao, Ying,Zhang, Zhi-Jun,Su, Jia,Shao, Li-Dong,&Zhao, Qin-Shi.(2017).A biomimetic semisynthesis enables structural elucidation of selaginellin U: a tautomeric cyclic alkynylphenol from Selaginella tamariscina.ROYAL SOCIETY OPEN SCIENCE,4(7),170352. |
| MLA | Zhu, Qin-Feng,et al."A biomimetic semisynthesis enables structural elucidation of selaginellin U: a tautomeric cyclic alkynylphenol from Selaginella tamariscina".ROYAL SOCIETY OPEN SCIENCE 4.7(2017):170352. |
入库方式： OAI收割
来源：昆明植物研究所
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