Potential role of CYP1B1 in the development and treatment of metabolic diseases
文献类型：期刊论文
| 作者 | Li, Fei1,2; Zhu, Weifeng3; Gonzalez, Frank J.1 |
| 刊名 | PHARMACOLOGY & THERAPEUTICS
 |
| 出版日期 | 2017-10-01 |
| 卷号 | 178页码:18-30 |
| 关键词 | Cyp1b1 Metabolic Diseases Metabolic Pathways Metabolomics |
| ISSN号 | 0163-7258 |
| DOI | 10.1016/j.pharmthera.2017.03.007 |
| 英文摘要 | Cytochrome P450 1B1 (CYP1B1), a member of CYP superfamily, is expressed in liver and extrahepatic tissues carries out the metabolism of numerous xenobiotics, including metabolic activation of polycyclic aromatic hydrocarbons. Surprisingly, CYP1B1 was also shown to be important in regulating endogenous metabolic pathways, including the metabolism of steroid hormones, fatty acids, melatonin, and vitamins. CYP1B1 and nuclear receptors including peroxisome proliferator-activated receptors (PPARs), estrogen receptor (ER), and retinoic acid receptors (RAR) contribute to the maintenance of the homeostasis of these endogenous compounds. Many natural flavonoids and synthetic stilbenes show inhibitory activity toward CYP1B1 expression and function, notably isorhamnetin and 2,4,3 ',5 '-tetramethoxystilbene. Accumulating evidence indicates that modulation of CYP1B1 can decrease adipogenesis and tumorigenesis, and prevent obesity, hypertension, atherosclerosis, and cancer. Therefore, it may be feasible to consider CYP1B1 as a therapeutic target for the treatment of metabolic diseases. Published by Elsevier Inc. |
| 语种 | 英语 |
| WOS记录号 | WOS:000412789100002 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/54997]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.NCI, Lab Metab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA 2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China 3.Jiangxi Univ Tradit Chinese Med, Res Ctr Differentiat & Dev Basic Theory Tradit Ch, Nanchang 330004, Jiangxi, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Fei,Zhu, Weifeng,Gonzalez, Frank J.. Potential role of CYP1B1 in the development and treatment of metabolic diseases[J]. PHARMACOLOGY & THERAPEUTICS,2017,178:18-30. |
| APA | Li, Fei,Zhu, Weifeng,&Gonzalez, Frank J..(2017).Potential role of CYP1B1 in the development and treatment of metabolic diseases.PHARMACOLOGY & THERAPEUTICS,178,18-30. |
| MLA | Li, Fei,et al."Potential role of CYP1B1 in the development and treatment of metabolic diseases".PHARMACOLOGY & THERAPEUTICS 178(2017):18-30. |
入库方式： OAI收割
来源：昆明植物研究所
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