Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis
文献类型：期刊论文
| 作者 | Nian, Yin1 ; Lu, Ni-Hong2; Liu, Xiao-Ling1; Li, Da-Shan1; Zhou, Lin1; Qiu, Ming-Hua1
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| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2018 |
| 卷号 | 8期号:14页码:7832-7838 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c8ra00291f |
| 英文摘要 | Two new cycloartane triterpenes, cimyunnin E (1), containing a unique oxaspiro [4.4] nonanedione moiety based on rings D and E, together with cimicifine B (2), a 25,26,27-trinortriterpene featuring a pyridine ring E, were purified from the fruits of Cimicifuga yunnanensis. Their structures were elucidated by spectroscopic methods and ECD (electronic circular dichroism calculations). Compounds 1 and 2 showed significant acetylcholinesterase (AChE) inhibition with IC50 values of 1.58 and 3.87 mu M, respectively. In addition, they noticeably enhanced the neurite outgrowth of nerve growth factor (NGF) mediated PC12 cells at a concentration of 10 mu M. |
| 语种 | 英语 |
| WOS记录号 | WOS:000425647000058 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/60450]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Third Peoples Hosp Kunming, Dept Resp Med, Kunming 650041, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Nian, Yin,Lu, Ni-Hong,Liu, Xiao-Ling,et al. Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis[J]. RSC ADVANCES,2018,8(14):7832-7838. |
| APA | Nian, Yin,Lu, Ni-Hong,Liu, Xiao-Ling,Li, Da-Shan,Zhou, Lin,&Qiu, Ming-Hua.(2018).Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis.RSC ADVANCES,8(14),7832-7838. |
| MLA | Nian, Yin,et al."Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis".RSC ADVANCES 8.14(2018):7832-7838. |
入库方式： OAI收割
来源：昆明植物研究所
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