Cytotoxic and renoprotective diterpenoids from Clerodendranthus spicatus
文献类型：期刊论文
| 作者 | Luo, Yong1,3; Li, Xiao-Zhen1,5; Xiang, Bin1; Luo, Qi1 ; Liu, Jia-Wang1,6; Yan, Yong-Ming1,6; Sun, Qin3,4; Cheng, Yong-Xian1,2,6
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2018-03-01 |
| 卷号 | 125页码:135-140 |
| 关键词 | Clerodendranthus Spicatus Diterpenoids Alkaloid Cytotoxic Activities Renal Fibrosis |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2018.01.003 |
| 英文摘要 | Three new diterpenoids, spicatusenes A-C (1-3), and eleven known ones (4-14) were isolated from the aerial parts of Clerodendranthus spicatus. Their structures were identified by spectroscopic methods. The cytotoxic activities of all the compounds against human cancer cells (HL-60, SMMC-7721, A-549, MCF-7, and SW-480) were examined and found that compounds 2, 3, 6, 8, 10, and 13 were active against one or more cancer cell lines. Besides, the renoprotective effects of all the isolates in TGF-beta 1-induced rat kidney fibroblasts revealed that compounds 3-7, 9, 13, and 14 were beneficial for renal fibrosis. Finally, a plausible biosynthetic pathway for 1 via a Hantzsch-type reaction was proposed. |
| 语种 | 英语 |
| WOS记录号 | WOS:000425560500022 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/60551]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Henan Univ Chinese Med, Zhengzhou 450008, Henan, Peoples R China 3.Southwest Med Univ, Chinese Med Hosp, Dept Pharmaceut Preparat, Luzhou 646000, Peoples R China 4.Southwest Med Univ, Luzhou 646000, Peoples R China 5.Yunnan Univ Tradit Chinese Med, Kunming 650500, Yunnan, Peoples R China 6.Shenzhen Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Sch Med,Guangdong Key Lab Genome Stabil & Dis Pre, Shenzhen 518060, Peoples R China |
| 推荐引用方式 GB/T 7714 | Luo, Yong,Li, Xiao-Zhen,Xiang, Bin,et al. Cytotoxic and renoprotective diterpenoids from Clerodendranthus spicatus[J]. FITOTERAPIA,2018,125:135-140. |
| APA | Luo, Yong.,Li, Xiao-Zhen.,Xiang, Bin.,Luo, Qi.,Liu, Jia-Wang.,...&Cheng, Yong-Xian.(2018).Cytotoxic and renoprotective diterpenoids from Clerodendranthus spicatus.FITOTERAPIA,125,135-140. |
| MLA | Luo, Yong,et al."Cytotoxic and renoprotective diterpenoids from Clerodendranthus spicatus".FITOTERAPIA 125(2018):135-140. |
入库方式： OAI收割
来源：昆明植物研究所
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