Polyoxygenated Cyclohexenoids with Promising alpha-Glycosidase Inhibitory Activity Produced by Phomopsis sp YE3250, an Endophytic Fungus Derived from Paeonia delavayi
文献类型：期刊论文
| 作者 | Huang, Rong2; Jiang, Bo-Guang1; Li, Xiao-Nian3; Wang, Ya-Ting1; Liu, Si-Si1; Zheng, Kai-Xuan1; He, Jian4; Wu, Shao-Hua1 |
| 刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
 |
| 出版日期 | 2018-02-07 |
| 卷号 | 66期号:5页码:1140-1146 |
| 关键词 | Phomopsis Paeonia Delavayi Polyoxygenated Cyclohexenoids Alpha-glucosidase Inhibitor |
| ISSN号 | 0021-8561 |
| DOI | 10.1021/acs.jafc.7b04998 |
| 英文摘要 | Seven new polyoxygenated cyclohexenoids, namely, phomopoxides A-G (1-7), were isolated from the fermentation broth extract of an endophytic fungal strain Phomopsis sp. YE3250 from the medicinal plant Paeonia delavayi Franch. The structures of these compounds were established by spectroscopic interpretation. The absolute configurations of compounds 1 and 4 were confirmed by X-ray crystallographic analysis and chemical derivative approach. All isolated compounds showed weak cytotoxic activities toward three human tumor cell lines (Hela, MCF-7, and NCI-H460) and weak antifungal activities against five pathogenic fungi (Candida albicans, Aspergillus niger, Pyricularia oryzae, Fusarium avenaceum, and Hormodendrum compactum). In addition, compounds 1-7 showed a promising a-glycosidase inhibitory activity with IC50 values of 1.47, 1.55, 1.83, 2.76, 2.88, 3.16, and 2.94 mM, respectively, as compared with a positive control of acarbose (IC50 = 1.22 mM). |
| 语种 | 英语 |
| WOS记录号 | WOS:000424851900011 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/60563]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Yunnan Univ, Yunnan Inst Microbiol, Key Lab Microbial Resources, Minist Educ, Kunming 650091, Yunnan, Peoples R China 2.Yunnan Univ, Sch Chem Sci & Technol, Kunming 650091, Yunnan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 4.Southern Med Univ, Sch Pharmaceut Sci, Grp Peptides & Nat Prod Res, Guangzhou 510515, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Rong,Jiang, Bo-Guang,Li, Xiao-Nian,et al. Polyoxygenated Cyclohexenoids with Promising alpha-Glycosidase Inhibitory Activity Produced by Phomopsis sp YE3250, an Endophytic Fungus Derived from Paeonia delavayi[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2018,66(5):1140-1146. |
| APA | Huang, Rong.,Jiang, Bo-Guang.,Li, Xiao-Nian.,Wang, Ya-Ting.,Liu, Si-Si.,...&Wu, Shao-Hua.(2018).Polyoxygenated Cyclohexenoids with Promising alpha-Glycosidase Inhibitory Activity Produced by Phomopsis sp YE3250, an Endophytic Fungus Derived from Paeonia delavayi.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,66(5),1140-1146. |
| MLA | Huang, Rong,et al."Polyoxygenated Cyclohexenoids with Promising alpha-Glycosidase Inhibitory Activity Produced by Phomopsis sp YE3250, an Endophytic Fungus Derived from Paeonia delavayi".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 66.5(2018):1140-1146. |
入库方式： OAI收割
来源：昆明植物研究所
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