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Alkaloids as Cyclooxygenase Inhibitors in Anticancer Drug Discovery

文献类型：期刊论文

作者Hashmi, Muhammad Ali1; Khan, Afsar1; Farooq, Umar1; Khan, Sehroon2
刊名CURRENT PROTEIN & PEPTIDE SCIENCE
出版日期2018
卷号19期号:3页码:292-301
关键词Anticancer Cyclooxygenase Cox-2 Alkaloids Enzyme Inhibition Anti-inflammatory Anti-tumor
ISSN号1389-2037
DOI10.2174/1389203718666170106103031
英文摘要Cancer is the leading cause of death worldwide and anticancer drug discovery is a very hot area of research at present. There are various factors which control and affect cancer, out of which enzymes like cyclooxygenase-2 (COX-2) play a vital role in the growth of tumor cells. Inhibition of this enzyme is a very useful target for the prevention of various types of cancers. Alkaloids are a diverse group of naturally occurring compounds which have shown great COX-2 inhibitory activity both in vitro and in vivo. In this mini-review, we have discussed different alkaloids with COX-2 inhibitory activities and anticancer potential which may act as leads in modern anticancer drug discovery. Different classes of alkaloids including isoquinoline alkaloids, indole alkaloids, piperidine alkaloids, quinazoline alkaloids, and various miscellaneous alkaloids obtained from natural sources have been discussed in detail in this review.
语种英语
WOS记录号WOS:000419465300004
源URL[http://ir.kib.ac.cn/handle/151853/60584]  
专题昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位1.COMSATS Inst Informat Technol, Dept Chem, Abbottabad 22060, Pakistan
2.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 560201, Yunnan, Peoples R China
推荐引用方式
GB/T 7714		 Hashmi, Muhammad Ali,Khan, Afsar,Farooq, Umar,et al. Alkaloids as Cyclooxygenase Inhibitors in Anticancer Drug Discovery[J]. CURRENT PROTEIN & PEPTIDE SCIENCE,2018,19(3):292-301.
APA Hashmi, Muhammad Ali,Khan, Afsar,Farooq, Umar,&Khan, Sehroon.(2018).Alkaloids as Cyclooxygenase Inhibitors in Anticancer Drug Discovery.CURRENT PROTEIN & PEPTIDE SCIENCE,19(3),292-301.
MLA Hashmi, Muhammad Ali,et al."Alkaloids as Cyclooxygenase Inhibitors in Anticancer Drug Discovery".CURRENT PROTEIN & PEPTIDE SCIENCE 19.3(2018):292-301.

入库方式： OAI收割

来源：昆明植物研究所

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