Vibsane-Type Diterpenoids from Viburnum odoratissimum and Their Cytotoxic and HSP90 Inhibitory Activities
文献类型：期刊论文
| 作者 | Zhu, Qin-Feng1,2; Qi, Yan-Yan1,2; Zhang, Zhi-Jun1,2; Fan, Min1,2 ; Bi, Ran1,2; Su, Jia1; Wu, Xing-De1; Shao, Li-Dong1; Zhao, Qin-Shi1
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| 刊名 | CHEMISTRY & BIODIVERSITY
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| 出版日期 | 2018-05-01 |
| 卷号 | 15期号:5页码:1800049 |
| 关键词 | Vibsane-type Diterpenoids Viburnum Odoratissimum Cytotoxicity Hsp90 Inhibitor |
| ISSN号 | 1612-1872 |
| DOI | 10.1002/cbdv.201800049 |
| 英文摘要 | Four new vibsane-type diterpenoids, vibsanol I (1), 15-hydroperoxyvibsanol A (2), 14-hydroperoxyvibsanol B (3), 15-O-methylvibsanin U (4), and a new natural product, 5,6-dihydrovibsanin B (5), as well as six known analogues, were isolated from the twigs and leaves of Viburnum odoratissimum. Their structures were elucidated by spectroscopic analyses and chemical derivatization method. All compounds showed different levels of cytotoxicity against five cell lines (HL-60, A-549, SMMC-7721, MCF-7, and SW480). Remarkably, 14,18-O-diacetyl-15-O-methylvibsanin U (4a) showed significant cytotoxicity against HL-60, A-549, SMMC-7721, MCF-7, and SW480, with IC50 values of 0.15 +/- 0.01, 0.69 +/- 0.01, 0.41 +/- 0.02, 0.75 +/- 0.03, and 0.48 +/- 0.03m, respectively. In addition, vibsanin K (10) was identified as a HSP90 inhibitor with an IC50 value of 19.16m. |
| 语种 | 英语 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/61333]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Qin-Feng,Qi, Yan-Yan,Zhang, Zhi-Jun,et al. Vibsane-Type Diterpenoids from Viburnum odoratissimum and Their Cytotoxic and HSP90 Inhibitory Activities[J]. CHEMISTRY & BIODIVERSITY,2018,15(5):1800049. |
| APA | Zhu, Qin-Feng.,Qi, Yan-Yan.,Zhang, Zhi-Jun.,Fan, Min.,Bi, Ran.,...&Zhao, Qin-Shi.(2018).Vibsane-Type Diterpenoids from Viburnum odoratissimum and Their Cytotoxic and HSP90 Inhibitory Activities.CHEMISTRY & BIODIVERSITY,15(5),1800049. |
| MLA | Zhu, Qin-Feng,et al."Vibsane-Type Diterpenoids from Viburnum odoratissimum and Their Cytotoxic and HSP90 Inhibitory Activities".CHEMISTRY & BIODIVERSITY 15.5(2018):1800049. |
入库方式： OAI收割
来源：昆明植物研究所
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