Total synthesis of (-)-akaol A via a conformational constraint strategy
文献类型：期刊论文
| 作者 | Liu, Hao-Miao1,2,3; Chen, Dong1,2,3; Xu, Wen-Dan1,2,3; Dang, Li-Zhi4; Qin, Hong-Bo1,2
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| 刊名 | ORGANIC CHEMISTRY FRONTIERS
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| 出版日期 | 2018-06-21 |
| 卷号 | 5期号:12页码:1886-1889 |
| ISSN号 | 2052-4129 |
| DOI | 10.1039/c8qo00375k |
| 英文摘要 | The enantioselective total synthesis of (-)-akaol A has been achieved. The key reaction features a well-designed Friedel-Crafts cyclization, which ensured a cis-fused B/C ring through a conformational constraint strategy. In marked control to trans-fused B/C ring cyclization promoted by a routine acid, the complete cis selective formation of the B/C ring was realized for the first time. Bistri-fluoromethane-sulfonimide promoted the key cyclization effectively. Our synthesis involves 13 steps from known aldehyde 2 and proceeds in 10.7% overall yield. |
| 语种 | 英语 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/61369]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Photochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.China Tobacco Yunnan Ind Co Ltd, Kunming 650231, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Hao-Miao,Chen, Dong,Xu, Wen-Dan,et al. Total synthesis of (-)-akaol A via a conformational constraint strategy[J]. ORGANIC CHEMISTRY FRONTIERS,2018,5(12):1886-1889. |
| APA | Liu, Hao-Miao,Chen, Dong,Xu, Wen-Dan,Dang, Li-Zhi,&Qin, Hong-Bo.(2018).Total synthesis of (-)-akaol A via a conformational constraint strategy.ORGANIC CHEMISTRY FRONTIERS,5(12),1886-1889. |
| MLA | Liu, Hao-Miao,et al."Total synthesis of (-)-akaol A via a conformational constraint strategy".ORGANIC CHEMISTRY FRONTIERS 5.12(2018):1886-1889. |
入库方式： OAI收割
来源：昆明植物研究所
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