Liquid chromatography-mass spectrometry combined with xanthine oxidase inhibition profiling for identifying the bioactive constituents from Cistanche deserticola
文献类型：期刊论文
| 作者 | Chen, Xinglong1,2; Deng, Zhentao1,2; Huang, Xiaoyan1,2; Geng, Changan1,2; Chen, Jijun1,2
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| 刊名 | INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
 |
| 出版日期 | 2018-07-01 |
| 卷号 | 430页码:1-7 |
| 关键词 | Lc-ms Xanthine Oxidase Inhibitor Anti-gout Mass Fragmentation Pathway Cistanche Deserticola |
| ISSN号 | 1387-3806 |
| DOI | 10.1016/j.ijms.2018.03.009 |
| 英文摘要 | Xanthine oxidase (XO) inhibitor can block the synthesis of uric acid and is regarded as one of the therapeutic approaches of gout. The anti-XO constituents in the stem of Cistanche deserticola were characterized though LC-MS combined with xanthine oxidase inhibition profiling method. Seven phenylethanoid glycosides (1-7) and two phenylpropanoid glycosides (8-9) were identified from the bioactive extracts. Isoacteoside (1), kankanoside G (4) and cistanoside F (8) displayed crucial activity against XO with the IC50 values of 46.91, 85.31 mu M and 36.41 mu M respectively. The main mass fragmentation pathways of phenylethanoid glycosides were the losses of glucosyl, rhamanopyranosyl and phenylethoxyl groups in positive ion mode and the elimination of caffeoyl unit in negative ion mode. It shows that the stem of Cistanche deserticola is a functional food which performs potent anti-gout activity. (C) 2018 Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/61386]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China 2.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Xinglong,Deng, Zhentao,Huang, Xiaoyan,et al. Liquid chromatography-mass spectrometry combined with xanthine oxidase inhibition profiling for identifying the bioactive constituents from Cistanche deserticola[J]. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY,2018,430:1-7. |
| APA | Chen, Xinglong,Deng, Zhentao,Huang, Xiaoyan,Geng, Changan,&Chen, Jijun.(2018).Liquid chromatography-mass spectrometry combined with xanthine oxidase inhibition profiling for identifying the bioactive constituents from Cistanche deserticola.INTERNATIONAL JOURNAL OF MASS SPECTROMETRY,430,1-7. |
| MLA | Chen, Xinglong,et al."Liquid chromatography-mass spectrometry combined with xanthine oxidase inhibition profiling for identifying the bioactive constituents from Cistanche deserticola".INTERNATIONAL JOURNAL OF MASS SPECTROMETRY 430(2018):1-7. |
入库方式： OAI收割
来源：昆明植物研究所
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