Structurally diverse diterpenoids from Isodon pharicus
文献类型：期刊论文
| 作者 | Hu, Zheng-Xi1,2; Xu, Hou-Chao1; Hu, Kun1 ; Liu, Miao1; Li, Xiao-Nian1; Li, Xing-Ren1; Du, Xue1; Zhang, Yong-Hui2; Puno, Pema-Tenzin1; Sun, Han-Dong1
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| 刊名 | ORGANIC CHEMISTRY FRONTIERS
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| 出版日期 | 2018-08-07 |
| 卷号 | 5期号:15页码:2379-2389 |
| ISSN号 | 2052-4129 |
| DOI | 10.1039/c8qo00477c |
| 英文摘要 | Twenty-one diterpenoids with diverse structures, including twelve new compounds (1-12), were isolated from the aerial parts of Isodon pharicus. Structurally, pharicusin A (1), composed of a benzoyl group coupled to a 7 alpha,20-epoxy-ent-kauranoid, represents an unprecedented C-27 meroditerpenoid; pharicusin B (2) is a novel trinorditerpenoid with an unreported 15,16,17-trinor-7 alpha,20-epoxy-ent-kaurane skeleton; pharicusin C (4) represents the first example of 7 alpha,20-epoxy-ent-atisane diterpenoids. Their structures were elucidated based on spectroscopic analysis, wherein the absolute configurations of 2 and 3 were further confirmed by single-crystal X-ray diffraction and computational analysis of the optical rotatory dispersion (ORD). Selected sixteen isolates were evaluated for their in vitro cytotoxicity against a small panel of human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480), and compounds 9, 10, 13, 16, and 18 exhibited significant inhibitory effects against all five cell lines, with IC50 values in the range of 0.37-6.03 mu M. |
| 语种 | 英语 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/61684]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Zheng-Xi,Xu, Hou-Chao,Hu, Kun,et al. Structurally diverse diterpenoids from Isodon pharicus[J]. ORGANIC CHEMISTRY FRONTIERS,2018,5(15):2379-2389. |
| APA | Hu, Zheng-Xi.,Xu, Hou-Chao.,Hu, Kun.,Liu, Miao.,Li, Xiao-Nian.,...&Sun, Han-Dong.(2018).Structurally diverse diterpenoids from Isodon pharicus.ORGANIC CHEMISTRY FRONTIERS,5(15),2379-2389. |
| MLA | Hu, Zheng-Xi,et al."Structurally diverse diterpenoids from Isodon pharicus".ORGANIC CHEMISTRY FRONTIERS 5.15(2018):2379-2389. |
入库方式： OAI收割
来源：昆明植物研究所
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