Absolute Configurations and Bioactivities of Guaiane-Type Sesquiterpenoids Isolated from Pogostemon cablin
文献类型：期刊论文
| 作者 | Zhou, Qin-Mei1,2; Chen, Ming-Hua3,4; Li, Xiao-Hong1,2; Peng, Cheng1,2; Lin, Da-Sheng5; Li, Xiao-Nian6; He, Yang1; Xiong, Liang1,2 |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2018-09-01 |
| 卷号 | 81期号:9页码:1919-1927 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.7b00690 |
| 英文摘要 | Seven novel guaiane sesquiterpenoids (1-7) and three known seco-guaianes were isolated from the volatile oil of Pogostemon cablin. Their structures including absolute configurations were determined by spectroscopic analyses, a modified Mosher's method, and X-ray diffraction and ECD data. The results indicated that the ECD Cotton effects arising from one or two nonconjugated olefinic chromophores could be applied to define the absolute configurations of guaiane sesquiterpenoids. Compounds 3 and 6 exhibited significant vasorelaxant activity against phenylephrine-induced and KCl-induced contractions of rat aorta rings [half-maximal effective concentration (EC50) of 3 against PHE-induced contraction, 5.4 mu M; EC50 of 6 against PHE- and KCl-induced contractions, 1.6 and 24.2 mu M, respectively]. They also showed antifungal activity against Candida albicans (minimum inhibitory concentrations, 500 and 300 mu M, respectively). In addition, 2 and 7-9 displayed a neuroprotective effect against glutamate-induced injury in PC12 cells. |
| 资助项目 | Outstanding Youth Science Foundation of Sichuan Province[2015JQO030] ; Outstanding Youth Science Foundation of Sichuan Province[2015JQO027] ; National Major Special Project for the Development of New Drugs in China[2017ZX09201001-008-001] ; Scientific Research Fund of Sichuan Provincial Education Department[15ZA0084] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000446276600001 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | Outstanding Youth Science Foundation of Sichuan Province ; National Major Special Project for the Development of New Drugs in China ; Scientific Research Fund of Sichuan Provincial Education Department |
| 源URL | [http://ir.kib.ac.cn/handle/151853/62767]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Peng, Cheng; Xiong, Liang |
| 作者单位 | 1.Chengdu Univ Tradit Chinese Med, State Key Lab Breeding Base Systemat Res Dev & Ut, Chengdu 611137, Sichuan, Peoples R China 2.Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Sichuan, Peoples R China 3.Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China 4.Peking Union Med Coll, Beijing 100050, Peoples R China 5.Chengdu Taihe Hlth Technol Grp Inc Ltd, Chengdu 610075, Sichuan, Peoples R China 6.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Qin-Mei,Chen, Ming-Hua,Li, Xiao-Hong,et al. Absolute Configurations and Bioactivities of Guaiane-Type Sesquiterpenoids Isolated from Pogostemon cablin[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(9):1919-1927. |
| APA | Zhou, Qin-Mei.,Chen, Ming-Hua.,Li, Xiao-Hong.,Peng, Cheng.,Lin, Da-Sheng.,...&Xiong, Liang.(2018).Absolute Configurations and Bioactivities of Guaiane-Type Sesquiterpenoids Isolated from Pogostemon cablin.JOURNAL OF NATURAL PRODUCTS,81(9),1919-1927. |
| MLA | Zhou, Qin-Mei,et al."Absolute Configurations and Bioactivities of Guaiane-Type Sesquiterpenoids Isolated from Pogostemon cablin".JOURNAL OF NATURAL PRODUCTS 81.9(2018):1919-1927. |
入库方式： OAI收割
来源：昆明植物研究所
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