Premnafulvol A: A Diterpenoid with a 6/5/7/3-Fused Tetracyclic Core and Its Biosynthetically Related Analogues from Premna fulva
文献类型：期刊论文
| 作者 | Pu, De-Bing1,3 ; Du, Bao-Wen2; Chen, Wen1; Gao, Jun-Bo3; Hu, Kun3; Shi, Nan2; Li, Yi-Ming1; Zhang, Xing-Jie1; Zhang, Rui-Han1; Li, Xiao-Nian3
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2018-10-05 |
| 卷号 | 20期号:19页码:6314-6317 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.8b02845 |
| 英文摘要 | Premnafulvol A (1), a unique diterpenoid featuring a 6/5/7/3-fused tetracyclic carbon skeleton, with three biosynthetically related analogues, premnafulvols B-D (2-4), were isolated from the aerial parts of Premna fulva. Structures of 1-4 were established by a combination of extensive spectroscopic analyses, quantum chemical calculations, and X-ray crystallography. Plausible biosynthetic pathways of 1-4 were proposed. Interestingly, 2 and 3 exhibited opposite effects on estrogen biosynthesis in human ovarian granulosa-like KGN cells by modulating the expression of aromatase. |
| 资助项目 | NSFC[81422046] ; NSFC[21561142003] ; NSFC[21372214] ; NSFC[21762048] ; NSFC[U1702286] ; Program for Changjiang Scholars and Innovative Research Team in University[IRT_17R94] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000447118200072 |
| 资助机构 | NSFC ; Program for Changjiang Scholars and Innovative Research Team in University |
| 源URL | [http://ir.kib.ac.cn/handle/151853/62772]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Wang, Fei; Xiao, Wei-Lie |
| 作者单位 | 1.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ & Yunnan Prov, Kunming 650091, Yunnan, Peoples R China 2.Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Sichuan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Pu, De-Bing,Du, Bao-Wen,Chen, Wen,et al. Premnafulvol A: A Diterpenoid with a 6/5/7/3-Fused Tetracyclic Core and Its Biosynthetically Related Analogues from Premna fulva[J]. ORGANIC LETTERS,2018,20(19):6314-6317. |
| APA | Pu, De-Bing.,Du, Bao-Wen.,Chen, Wen.,Gao, Jun-Bo.,Hu, Kun.,...&Xiao, Wei-Lie.(2018).Premnafulvol A: A Diterpenoid with a 6/5/7/3-Fused Tetracyclic Core and Its Biosynthetically Related Analogues from Premna fulva.ORGANIC LETTERS,20(19),6314-6317. |
| MLA | Pu, De-Bing,et al."Premnafulvol A: A Diterpenoid with a 6/5/7/3-Fused Tetracyclic Core and Its Biosynthetically Related Analogues from Premna fulva".ORGANIC LETTERS 20.19(2018):6314-6317. |
入库方式： OAI收割
来源：昆明植物研究所
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