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Total Synthesis of Asperchalasines A, D, E, and H

文献类型：期刊论文

作者Long, Xianwen1,2,3; Ding, Yiming1,2; Deng, Jun1,2
刊名ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
出版日期2018-10-22
卷号57期号:43页码:14221-14224
关键词biomimetic synthesis cycloaddition dimers natural products total synthesis
ISSN号1433-7851
DOI10.1002/anie.201808481
英文摘要The first total syntheses of the cytochalasan dimers asperchalasines A, D, E, and H have been accomplished. The key steps of the synthesis include a highly stereoselective intermolecular Diels-Alder reaction and a Horner-Wads-worth-Emmons macrocyclization to establish the key monomer aspochalasin B, and an intermolecular Diels-Alder reaction followed by a biomimetic oxidative heterodimerization by 5+2 cycloaddition to furnish asperchalasine A. The synthetic efforts provide insight into the biosynthetic pathway of cytochalasan dimers and enables the further study of their biological properties.
资助项目CAS Pioneer Hundred Talents Program[2017-022] ; National Natural Science Foundaion of China[21871278] ; Kunming Institute of Botany
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000447371500043
出版者WILEY-V C H VERLAG GMBH
资助机构CAS Pioneer Hundred Talents Program ; National Natural Science Foundaion of China ; Kunming Institute of Botany
源URL[http://ir.kib.ac.cn/handle/151853/62773]  
专题昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者Deng, Jun
作者单位1.Chinese Acad Sci, Dept State Key Lab Phytochem & Plant Resources We, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Yunnan Key Lab Nat Med Chem, Kunming Inst Bot, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Long, Xianwen,Ding, Yiming,Deng, Jun. Total Synthesis of Asperchalasines A, D, E, and H[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(43):14221-14224.
APA Long, Xianwen,Ding, Yiming,&Deng, Jun.(2018).Total Synthesis of Asperchalasines A, D, E, and H.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(43),14221-14224.
MLA Long, Xianwen,et al."Total Synthesis of Asperchalasines A, D, E, and H".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.43(2018):14221-14224.

入库方式： OAI收割

来源：昆明植物研究所

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