中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 昆明植物研究所
  3. 中国科学院昆明植物研究所
  4. 植物化学与西部植物资源持续利用国家重点实验室
BACE1 Inhibitory Meroterpenoids from Aspergillus terreus

文献类型：期刊论文

作者Qi, Changxing1; Liu, Mengting1; Zhou, Qun1; Gao, Weixi1; Chen, Chunmei1; Lai, Yongji2; Hu, Zhengxi1; Xue, Yongbo1; Zhang, Jinwen3; Li, Dongyan3
刊名JOURNAL OF NATURAL PRODUCTS
出版日期2018-09-01
卷号81期号:9页码:1937-1945
ISSN号0163-3864
DOI10.1021/acs.jnatprod.7b01050
英文摘要Sixteen 3,5-dimethylorsellinic acid-based (DMOA-based) meroterpenoids, including 10 new compounds, asperterpenes D-M (1-10), were obtained from Aspergillus terreus. The structures and absolute configurations of the new compounds were confirmed by extensive spectroscopy, single-crystal X-ray diffraction analysis, and experimental electronic circular dichroism (ECD) measurements. Compounds 2, 3, and 7 are the first 3,5-dimethylorsellinic acid-based meroterpenoids possessing a unique cis-fused A/B ring system. These new compounds were evaluated for their inhibitory activity against beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1). Compounds 2, 3, and 7, the first 3,5-dimethylorsellinic acid based meroterpenoids possessing cis-fused A/B rings, exhibited significant inhibitory activities against BACE1 with IC50 values of 3.3, 5.9, and 31.7 mu M, respectively.
资助项目National Natural Science Foundation of China[81502943] ; National Natural Science Foundation of China[31600266] ; National Natural Science Foundation of China[81573316] ; National Natural Science Foundation of China[21602068] ; National Natural Science Foundation of China[31670354] ; National Natural Science Foundation of China[31370372] ; National Natural Science Foundation of China[21702067] ; Program for Changjiang Scholars[T2016088] ; China Postdoctoral Science Foundation[2018M632879] ; China Postdoctoral Science Foundation[2017M610479] ; National Science Fund for Distinguished Young Scholars[81725021] ; Academic Frontier Youth Team of HUST ; Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College (HUST) ; Innovative Research Groups of the National Natural Science Foundation of China[81721005]
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000446276600003
出版者AMER CHEMICAL SOC
资助机构National Natural Science Foundation of China ; Program for Changjiang Scholars ; China Postdoctoral Science Foundation ; National Science Fund for Distinguished Young Scholars ; Academic Frontier Youth Team of HUST ; Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College (HUST) ; Innovative Research Groups of the National Natural Science Foundation of China
源URL[http://ir.kib.ac.cn/handle/151853/62789]  
专题昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者Wang, Jianping; Zhu, Hucheng; Zhang, Yonghui
作者单位1.Huazhong Univ Sci & Technol, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China
2.Huazhong Univ Sci & Technol, Tongji Med Coll, Cent Hosp Wuhan, Dept Pharm, Wuhan 430030, Hubei, Peoples R China
3.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Pharm, Wuhan 430030, Hubei, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
推荐引用方式
GB/T 7714		 Qi, Changxing,Liu, Mengting,Zhou, Qun,et al. BACE1 Inhibitory Meroterpenoids from Aspergillus terreus[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(9):1937-1945.
APA Qi, Changxing.,Liu, Mengting.,Zhou, Qun.,Gao, Weixi.,Chen, Chunmei.,...&Zhang, Yonghui.(2018).BACE1 Inhibitory Meroterpenoids from Aspergillus terreus.JOURNAL OF NATURAL PRODUCTS,81(9),1937-1945.
MLA Qi, Changxing,et al."BACE1 Inhibitory Meroterpenoids from Aspergillus terreus".JOURNAL OF NATURAL PRODUCTS 81.9(2018):1937-1945.

入库方式： OAI收割

来源：昆明植物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。