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Phyllaemblicin B inhibits Coxsackie virus B3 induced apoptosis and myocarditis

文献类型：期刊论文

作者Ya-Feng, Wang1,2; Xiao-Yan, Wang1,2; Zhe, Ren1,2; Chui-Wen, Qian1,2; Yi-Cheng, Li1,2; Kitazato, Kaio1,3; Qing-Duan, Wang4; Yan, Zhang4; Li-Yun, Zheng4; Jin-Hua, Jiang4
刊名ANTIVIRAL RESEARCH
出版日期2009-11-01
卷号84期号:2页码:150-158
关键词Coxsackie Virus B3 Viral Myocarditis Phyllaemblicin b Antiviral Effect Apoptosis
ISSN号0166-3542
DOI10.1016/j.antiviral.2009.08.004
通讯作者twang-yf@163.com
文献子类Article
英文摘要Coxsackie virus B3 (CVB3) is believed to be a major contributor to viral myocarditis since virus-associated apoptosis plays a role in the pathogenesis of experimental myocarditis. in this study, we investigated the in vitro and in vivo antiviral activities of Phyllaemblicin B, the main ellagitannin compound isolated from Phyllanthus emblica, a Chinese herb medicine, against CVB3. Herein we report that Phyllaemblicin B inhibited CVB3-mediated cytopathic effects on HeLa cells with an IC50 value of 7.75 +/- 0.15 mu g/mL In an in vivo assay, treatment with 12 mg kg(-1) d(-1) Phyllaemblicin B reduced cardiac CVB3 titers, decreased the activities of LDH and CK in murine serum, and alleviated pathological damages of cardiac muscle in myocarditic mice. Moreover, Phyllaemblicin B clearly inhibited CVB3-associated apoptosis effects both in vitro and in vivo. These results show that Phyllaemblicin B exerts significant antiviral activities against Phyllaemblicin B may represent a potential therapeutic agent for viral myocarditis. Therefore CVB3. (C) 2009 Elsevier B.V. All rights reserved.
学科主题Pharmacology & Pharmacy ; Virology
WOS关键词DILATED CARDIOMYOPATHY ; B3-INDUCED MYOCARDITIS ; VIRAL MYOCARDITIS ; GLUTATHIONE-PEROXIDASE ; CYTOCHROME-C ; IN-VITRO ; INFECTION ; ACTIVATION ; RELEASE ; CELLS
WOS研究方向Pharmacology & Pharmacy ; Virology
语种英语
WOS记录号WOS:000271171800005
资助机构This study was supported by the joint Funds of National Science Foundation of China (U0632010), the State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences (P2008-KF07, P2008-ZZ08) and "211 grant of the Ministry of Education (MOE)".
公开日期2011-12-06
源URL[http://ir.kib.ac.cn:8080/handle/151853/2399]  
专题昆明植物研究所_资源植物与生物技术所级重点实验室
作者单位1.Jinan Univ, Inst Pharmacol Sci, Guangzhou 510630, Guangdong, Peoples R China
2.Natl Engn Res Ctr Genet Med, Guangzhou 510630, Guangdong, Peoples R China
3.Nagasaki Univ, Dept Mol Microbiol & Immunol, Grad Sch Biomed Sci, Lab Mol Biol Infect Agents, Nagasaki 852, Japan
4.Zhengzhou Univ, Henan Acad Med & Pharmaceut Sci, Zhengzhou 450000, Henan, Peoples R China
5.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
推荐引用方式
GB/T 7714		 Ya-Feng, Wang,Xiao-Yan, Wang,Zhe, Ren,et al. Phyllaemblicin B inhibits Coxsackie virus B3 induced apoptosis and myocarditis[J]. ANTIVIRAL RESEARCH,2009,84(2):150-158.
APA Ya-Feng, Wang.,Xiao-Yan, Wang.,Zhe, Ren.,Chui-Wen, Qian.,Yi-Cheng, Li.,...&Yi-Fei, Wang.(2009).Phyllaemblicin B inhibits Coxsackie virus B3 induced apoptosis and myocarditis.ANTIVIRAL RESEARCH,84(2),150-158.
MLA Ya-Feng, Wang,et al."Phyllaemblicin B inhibits Coxsackie virus B3 induced apoptosis and myocarditis".ANTIVIRAL RESEARCH 84.2(2009):150-158.

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来源：昆明植物研究所

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