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Chemical constituents of Aeschynanthus bracteatus and their weak anti-inflammatory activities

文献类型：期刊论文

作者Li, Su-Mei1,2,3; Yang, Xian-Wen2; Shen, Yun-Heng2; Feng, Lin4; Wang, Yue-Hu1; Zeng, Hua-Wu2; Liu, Xiao-Hua2; Tian, Jun-Mian2; Shi, Ya-Na1; Long, Chun-Lin1,5
刊名PHYTOCHEMISTRY
出版日期2008-08-01
卷号69期号:11页码:2200-2204
关键词Aeschynanthus Bracteatus Gesneriaceae Phenylethanoids Aeschynanthosides A-d Raw 264.7 Macrophages Anti-inflammatory No
ISSN号0031-9422
DOI10.1016/j.phytochem.2008.05.012
通讯作者long@mail.kib.ac.cn ; wdzhangy@hotmail.com
文献子类Article
英文摘要Chemical examination of the EtOAc extract from the aerial parts of Aeschynanthus bracteatus led to isolation of four phenylethanol glycosides, aeschynanthosides A-D (1-4), and 55 known constituents, including 8 phenylethanoids, 23 phenols, 5 lignans, 7 flavonoids, 9 terpenoids, and 4 others. Their structures were elucidated mainly by detailed spectroscopic studies and comparison with published data. All 59 compounds were isolated for the first time from an Aeschynanthus species. The isolates were also tested for inhibitory activities against LPS-induced NO production in RAW 264.7 macrophages. Aeschynanthoside D (4) and naringenin (41), within the concentration arrange tested (50-100 mu g/mL), showed very weak dose-dependent effects with the inhibition rate of 24.2%, 35.4%, 66.0%, and 9.5%, 40.1%, 65.0%, respectively, relative to positive controls. (C) 2008 Elsevier Ltd. All rights reserved.
学科主题Biochemistry & Molecular Biology ; Plant Sciences
WOS关键词MEDICINAL-PLANTS ; GLYCOSIDES ; GLUCOSIDES ; CHINA ; DERIVATIVES ; LIGNAN ; ESTERS
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
语种英语
WOS记录号WOS:000258863100015
资助机构We acknowledge the Department of Instrumental Analysis of the Second Military Medical University for measuring UV, IR, NMR spectra, and the Shanghai Institute of Organic Chemistry for measuring the optical rotations. We wish to thank Guangwan Hu and Lvliu Zou who helped in collection of plant material. Thanks are also expressed to Professor Heng Li, a botanist at Kunming Institute of Botany, who helped in identification of the plants collected from the fields. This research was supported by the Ministry of Science and Technology of China (Nos. 2004DKA30430, 2005DKA21006), and the Ministry of Education of China through its 111 Project (B08044, CUN 985-3-3).
公开日期2011-12-06
源URL[http://ir.kib.ac.cn:8080/handle/151853/2495]  
专题昆明植物研究所_资源植物与生物技术所级重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Second Mil Med Univ, Dept Nat Prod Chem, Sch Pharm, Shanghai 200433, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
4.Jiangxi Univ Tradit Chinese Med, Dept Pharm, Nanchang 330004, Peoples R China
5.Cent Univ Nationalities, Coll Life & Environm Sci, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714		 Li, Su-Mei,Yang, Xian-Wen,Shen, Yun-Heng,et al. Chemical constituents of Aeschynanthus bracteatus and their weak anti-inflammatory activities[J]. PHYTOCHEMISTRY,2008,69(11):2200-2204.
APA Li, Su-Mei.,Yang, Xian-Wen.,Shen, Yun-Heng.,Feng, Lin.,Wang, Yue-Hu.,...&Zhang, Wei-Dong.(2008).Chemical constituents of Aeschynanthus bracteatus and their weak anti-inflammatory activities.PHYTOCHEMISTRY,69(11),2200-2204.
MLA Li, Su-Mei,et al."Chemical constituents of Aeschynanthus bracteatus and their weak anti-inflammatory activities".PHYTOCHEMISTRY 69.11(2008):2200-2204.

入库方式： OAI收割

来源：昆明植物研究所

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