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Chemical Constituents of Excoecaria acerifolia and Their Bioactivities

文献类型：期刊论文

作者Zhao, Yan-Li1,2; He, Qiu-Xia3; Li, Yang1; Wang, Si-Feng3; Liu, Ke-Chun3; Yang, Yong-Ping1,4; Li, Xiao-Li1,4
刊名MOLECULES
出版日期2010-04-01
卷号15期号:4页码:2178-2186
关键词Kaurane Diterpenoid Excoecaria Acerifolia Nmr Antiangiogenic Antiproliferative
ISSN号1420-3049
DOI10.3390/molecules15042178
文献子类Article
英文摘要A new kaurane diterpenoid, 3 alpha, 18-dihydroxy-3 beta,20-epoxykaur-15-ene (1), was isolated from the aerial parts of Excoecaria acerifolia (Euphorbiaceae) together with 16 known compounds. Their structures were identified by extensive spectral analysis, especially 2D NMR techniques. Antiangiogenic effects of compounds 1-6 and 9-17 were evaluated using a zebrafish model, with compound 9 being active in this bioassay. At the same time, compounds 4, 6, 10, 11 showed activity in inhibiting the growth of A549 lung cancer cells, and the compound 10 also showed apoptosis-inducing effects on A549 lung cancer cells.; A new kaurane diterpenoid, 3 alpha, 18-dihydroxy-3 beta,20-epoxykaur-15-ene (1), was isolated from the aerial parts of Excoecaria acerifolia (Euphorbiaceae) together with 16 known compounds. Their structures were identified by extensive spectral analysis, especially 2D NMR techniques. Antiangiogenic effects of compounds 1-6 and 9-17 were evaluated using a zebrafish model, with compound 9 being active in this bioassay. At the same time, compounds 4, 6, 10, 11 showed activity in inhibiting the growth of A549 lung cancer cells, and the compound 10 also showed apoptosis-inducing effects on A549 lung cancer cells.
学科主题Chemistry, Organic
WOS关键词DITERPENOIDS ; GLYCOSIDES ; AGALLOCHA
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000277147400012
资助机构West Light Foundation of the Chinese Academy of Sciences ; MOST [2008BAD98B06]; MAPPA/ICIMOD ; Ford Foundation [1075-0729, 1090-0448]
公开日期2011-12-06
源URL[http://ir.kib.ac.cn:8080/handle/151853/2617]  
专题昆明植物研究所_中国科学院青藏高原研究所昆明部
作者单位1.Chinese Acad Sci, Kunming Inst Bot, Lab Ethnobot, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
3.Shandong Acad Sci, Inst Biol, Jinan 250014, Shandong, Peoples R China
4.Chinese Acad Sci, Inst Tibetan Plateau Res Kunming, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
推荐引用方式
GB/T 7714		 Zhao, Yan-Li,He, Qiu-Xia,Li, Yang,et al. Chemical Constituents of Excoecaria acerifolia and Their Bioactivities[J]. MOLECULES,2010,15(4):2178-2186.
APA Zhao, Yan-Li.,He, Qiu-Xia.,Li, Yang.,Wang, Si-Feng.,Liu, Ke-Chun.,...&Li, Xiao-Li.(2010).Chemical Constituents of Excoecaria acerifolia and Their Bioactivities.MOLECULES,15(4),2178-2186.
MLA Zhao, Yan-Li,et al."Chemical Constituents of Excoecaria acerifolia and Their Bioactivities".MOLECULES 15.4(2010):2178-2186.

入库方式： OAI收割

来源：昆明植物研究所

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