Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A
文献类型：期刊论文
| 作者 | Yuan, WJ (Yuan, Wen-Juan)[ 1,2,3 ]; Ding, X (Ding, Xiao)[ 1 ]; Wang, Z (Wang, Zhe)[ 1 ]; Yang, BJ (Yang, Bi-Juan)[ 1 ]; Li, XN (Li, Xiao-Nian)[ 1 ]; Zhang, Y (Zhang, Yu)[ 1 ]; Chen, DZ (Chen, Duo-Zhi)[ 1 ]; Li, SL (Li, Shun-Lin)[ 1 ]; Chen, Q (Chen, Quan)[ 4 ]; Di, YT (Di, Ying-Tong)[ 1 ] |
| 刊名 | SCIENTIFIC REPORTS
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| 出版日期 | 2017 |
| 卷号 | 7期号:11页码:1-9 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-017-14637-w |
| 英文摘要 | Rare ent-abietane-rosane diterpenoid heterodimers, Bisebracteolasins A and B (1 and 2, respectively), were isolated from the roots of Euphorbia ebracteolata Hayata. Their structures and absolute configurations were elucidated from spectroscopic data and X-ray diffraction analysis. Compounds 1 and 2 exhibited moderate cytotoxic effects against five cancer cell lines. Compound 1 showed more effective antiproliferative activities against human tumour cells, HL-60 and SMMC-7721, with IC50 values of 2.61 and 4.08 mu M, respectively, than 2. Both compounds 1 and 2 inhibit the colorectal cancer stem cell line P6C with IC50 values of 16.48 and 34.76 mu M, respectively. Moreover, preliminary biological tests showed compound 1 exhibited inhibitory activity towards tumoursphere formation and migration of the P6C cell line. Overall, we identified two novel diterpenoid heterodimers, and Bisebracteolasin A exhibits therapeutic potential in impeding tumour growth and metastatic ability of cancer stem cells. |
| WOS记录号 | WOS:000414415000007 |
| 源URL | [http://ir.xjipc.cas.cn/handle/365002/5022]  |
| 专题 | 新疆理化技术研究所_资源化学研究室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China 2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Xinjiang, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, WJ ,Ding, X ,Wang, Z ,et al. Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A[J]. SCIENTIFIC REPORTS,2017,7(11):1-9. |
| APA | Yuan, WJ .,Ding, X .,Wang, Z .,Yang, BJ .,Li, XN .,...&Hao, XJ .(2017).Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A.SCIENTIFIC REPORTS,7(11),1-9. |
| MLA | Yuan, WJ ,et al."Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A".SCIENTIFIC REPORTS 7.11(2017):1-9. |
入库方式： OAI收割
来源：新疆理化技术研究所
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