Polyacetylenes from the florets of Carthamus tinctorius and their cytotoxicity
文献类型：期刊论文
| 作者 | Liu, YS (Liu, Yushuang); Xue, JJ (Xue, Jingjing); Han, JX (Han, Jianxin); Hua, HM (Hua, Huiming); Yuan, T (Yuan, Tao) |
| 刊名 | PHYTOCHEMISTRY LETTERS
 |
| 出版日期 | 2018 |
| 卷号 | 23期号:2页码:168-171 |
| 关键词 | Carthamus Tinctorius Compositae Polyacetylenes Circular Dichroism Cytotoxicity |
| ISSN号 | 1874-3900 |
| DOI | 10.1016/j.phytol.2017.12.006 |
| 英文摘要 | Two new polyacetylenes, (2R, 11S, 12S)-(3E)-tridecene-5,7,9-triyne-1,2,11,12-tetraol (1) and (8S)-deca-4,6-diyne-1,8-diol-8-O-beta-D-glucopyranoside (2), together with six known polyacetylenes (3-8), were isolated from the florets of Carthamus tinctorius. Their structures were elucidated on the basis of spectroscopic data (NMR and HRMS) and Mo2(OAc) 4-induced circular dichroism. Compounds 4 and 5 were cytotoxic to the human cancer cell lines HL-60 (IC50=6.40, 3.66 mu M), THP-1 (IC50=8.67, 6.69 mu M) and PC-3 (IC50=11.30, 10.92 mu M), comparable to the positive control, fluorouracil (IC50=2.58, 3.95 and 22.35 mu M, respectively). |
| WOS记录号 | WOS:000426096600031 |
| 源URL | [http://ir.xjipc.cas.cn/handle/365002/5240]  |
| 专题 | 新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室 |
| 通讯作者 | Yuan, T (Yuan, Tao) |
| 作者单位 | 1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China 2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Xinjiang Indigenous Med Plants Reso, Urumqi 830011, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, YS ,Xue, JJ ,Han, JX ,et al. Polyacetylenes from the florets of Carthamus tinctorius and their cytotoxicity[J]. PHYTOCHEMISTRY LETTERS,2018,23(2):168-171. |
| APA | Liu, YS ,Xue, JJ ,Han, JX ,Hua, HM ,&Yuan, T .(2018).Polyacetylenes from the florets of Carthamus tinctorius and their cytotoxicity.PHYTOCHEMISTRY LETTERS,23(2),168-171. |
| MLA | Liu, YS ,et al."Polyacetylenes from the florets of Carthamus tinctorius and their cytotoxicity".PHYTOCHEMISTRY LETTERS 23.2(2018):168-171. |
入库方式： OAI收割
来源：新疆理化技术研究所
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