Fabrication and effect on regulating vSMC phenotype of a biomimetic tunica media scaffold
文献类型：期刊论文
| 作者 | Shen, Hong1; Hu, Xixue2; Cui, Haiyan3; Zhuang, Yaping1,4; Huang, Da1,4; Yang, Fei1,4; Wang, Xing1; Wang, Shenguo1; Wu, Decheng1,4 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2016-12-21 |
| 卷号 | 4期号:47页码:7689-7696 |
| 英文摘要 | An ideal vascular tissue engineering scaffold should imitate physical and biochemical cues in native vessels for guiding cell growth, differentiation and tissue formation. The tunica media provides a key structure and function support for native vessels. In this study, a film-like MNP-TGF/bFGF-PLGA scaffold that simulated physical and biochemical cues of tunica media in native vessels was fabricated by soft lithography combined with solution casting and phase separation technique. The scaffold had dual surface topographies of parallel arranged microgrooves and nanofiber structures, and interconnected pores to be able to deliver nutrient and eliminate metabolized products. The TGF-beta 1 and bFGF immobilized on the scaffold by silica nanoparticle binding and plasma treatment technique could maintain continuous release for 10 and 7 days, respectively. The synergy effect of the dual surface topography and released growth factors endowed the MNP-TGF/bFGF-PLGA scaffold with good capacity on regulating vascular smooth muscle cell (vSMC) phenotype. Importantly, the scaffold possessed good mechanical properties and could easily be rolled into a multilayer cylindrical tube as a promising biomimic vascular tissue engineering scaffold. |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/38017]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 3.Shanghai Jiao Tong Univ, Sch Med, Peoples Hosp 9, Shanghai 200011, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shen, Hong,Hu, Xixue,Cui, Haiyan,et al. Fabrication and effect on regulating vSMC phenotype of a biomimetic tunica media scaffold[J]. JOURNAL OF MATERIALS CHEMISTRY B,2016,4(47):7689-7696. |
| APA | Shen, Hong.,Hu, Xixue.,Cui, Haiyan.,Zhuang, Yaping.,Huang, Da.,...&Wu, Decheng.(2016).Fabrication and effect on regulating vSMC phenotype of a biomimetic tunica media scaffold.JOURNAL OF MATERIALS CHEMISTRY B,4(47),7689-7696. |
| MLA | Shen, Hong,et al."Fabrication and effect on regulating vSMC phenotype of a biomimetic tunica media scaffold".JOURNAL OF MATERIALS CHEMISTRY B 4.47(2016):7689-7696. |
入库方式： OAI收割
来源：化学研究所
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